Hospital-Associated Multicenter Outbreak of Emerging Fungus Candida auris, Colombia, 2016.

Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE

Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-

Candida*/drug effects ; Cross Infection* ; Disease Outbreaks*; Candidiasis/*epidemiology ; Candidiasis/*microbiology ; Communicable Diseases, Emerging/*epidemiology ; Communicable Diseases, Emerging/*microbiology; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candidemia/epidemiology ; Candidemia/microbiology ; Candidiasis/drug therapy ; Candidiasis/history ; Child ; Child, Preschool ; Colombia/epidemiology ; Communicable Diseases, Emerging/history ; Drug Resistance, Fungal ; Female ; History, 21st Century ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Mortality ; Patient Outcome Assessment ; Public Health Surveillance ; Seasons ; Young Adult

Candida auris is an emerging multidrug-resistant fungus that causes hospital-associated outbreaks of invasive infections with high death rates. During 2015-2016, health authorities in Colombia detected an outbreak of C. auris. We conducted an investigation to characterize the epidemiology, transmission mechanisms, and reservoirs of this organism. We investigated 4 hospitals with confirmed cases of C. auris candidemia in 3 cities in Colombia. We abstracted medical records and collected swabs from contemporaneously hospitalized patients to assess for skin colonization. We identified 40 cases; median patient age was 23 years (IQR 4 months-56 years). Twelve (30%) patients were <1 year of age, and 24 (60%) were male. The 30-day mortality was 43%. Cases clustered in time and location; axilla and groin were the most commonly colonized sites. Temporal and spatial clustering of cases and skin colonization suggest person-to-person transmission of C. auris. These cases highlight the importance of adherence to infection control recommendations.

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Keywords: Candida auris; Colombia; antimicrobial resistance; candidemia; fungi; healthcare-associated; nosocomial infections

0 (Antifungal Agents)

Date Created: 20190619 Date Completed: 20191223 Latest Revision: 20200309

20240104

PMC6590770

10.3201/eid2507.180491

31211679