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Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations.

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  • Additional Information
    • Corporate Authors:
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
    • Abstract:
      Host genetic factors have been suggested to play an important role in the susceptibility to Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the disease, in the present study, we analyzed three IL18 genetic variants (rs2043055, rs1946518, rs360719) regarding the predisposition to Trypanosoma cruzi infection and the development of chronic Chagas cardiomyopathy (CCC), in different Latin America populations. Genetic data of 3,608 patients from Colombia, Bolivia, Argentina, and Brazil were meta-analyzed to validate previous findings with increased statistical power. Seropositive and seronegative individuals were compared for T. cruzi infection susceptibility. In the Colombian cohort, the allelic frequencies of the three variants showed a significant association, with adjustment for sex and age, and also after applying multiple testing adjustments. Among the Colombian and Argentinean cohorts, rs360719 showed a significant genetic effect in a fixed-effects meta-analysis after a Bonferroni correction (OR: 0.76, CI: 0.66-0.89, P = 0.001). For CCC, the rs2043055 showed an association with protection from cardiomyopathy in the Colombian cohort (OR: 0.79, CI: 0.64-0.99, P = 0.037), with adjustment for sex and age, and after applying multiple testing adjustments. The meta-analysis of the CCC vs. asymptomatic patients from the four cohorts showed no evidence of association. In conclusion, our results validated the association found previously in the Colombian cohort suggesting that IL18 rs360719 plays an important role in the susceptibility to T. cruzi infection and no evidence of association was found between the IL18 genetic variants and CCC in the Latin American population studied.
      Competing Interests: The authors have declared that no competing interests exist.
    • References:
      PLoS Negl Trop Dis. 2016 May 16;10(5):e0004724. (PMID: 27182885)
      Expert Rev Cardiovasc Ther. 2017 Apr 19;:1-10. (PMID: 28388241)
      Lancet. 2018 Jan 6;391(10115):82-94. (PMID: 28673423)
      Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1:31-40. (PMID: 19753455)
      Nature. 2012 Nov 1;491(7422):56-65. (PMID: 23128226)
      PLoS Negl Trop Dis. 2016 Mar 30;10(3):e0004583. (PMID: 27027876)
      Front Immunol. 2018 Dec 03;9:2791. (PMID: 30559742)
      Acta Trop. 2019 Sep;197:105062. (PMID: 31201776)
      Hum Mol Genet. 2009 Oct 1;18(19):3739-48. (PMID: 19584085)
      Expert Rev Mol Med. 2010 Sep 15;12:e29. (PMID: 20840799)
      PLoS One. 2019 Jun 17;14(6):e0214830. (PMID: 31206551)
      Nucleic Acids Res. 2016 Jan 4;44(D1):D877-81. (PMID: 26657631)
      Bioessays. 2015 Mar;37(3):314-23. (PMID: 25450156)
      Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2:8954-61. (PMID: 20445096)
      Int J Immunogenet. 2007 Apr;34(2):75-9. (PMID: 17373930)
      Genet Med. 2002 Mar-Apr;4(2):45-61. (PMID: 11882781)
      Trends Immunol. 2014 Oct;35(10):483-94. (PMID: 25182198)
      PLoS Pathog. 2019 Jan 4;15(1):e1007456. (PMID: 30608984)
      Am J Hum Genet. 2011 May 13;88(5):586-98. (PMID: 21565292)
      Mediators Inflamm. 2014;2014:683230. (PMID: 25210230)
      Int J Mol Sci. 2019 Feb 02;20(3):null. (PMID: 30717382)
      Evolution. 2000 Feb;54(1):51-63. (PMID: 10937183)
      Microbes Infect. 2014 Jun;16(6):481-90. (PMID: 24704475)
      J Immunol. 2001 Sep 15;167(6):3346-53. (PMID: 11544324)
      Nat Genet. 2003 Feb;33(2):177-82. (PMID: 12524541)
      Mediators Inflamm. 2014;2014:914326. (PMID: 25152568)
      Front Immunol. 2018 Apr 11;9:615. (PMID: 29696014)
      Mol Biol Evol. 2019 Jun 1;36(6):1254-1269. (PMID: 30895292)
      Am J Hum Genet. 2018 May 3;102(5):806-815. (PMID: 29706345)
      Mem Inst Oswaldo Cruz. 2018 May 14;113(6):e170489. (PMID: 29768622)
      Nat Genet. 2006 Feb;38(2):209-13. (PMID: 16415888)
      Immunol Lett. 2001 Dec 3;79(3):189-96. (PMID: 11600197)
      Ophthalmic Physiol Opt. 2014 Sep;34(5):502-8. (PMID: 24697967)
      BMC Genomics. 2018 Dec 11;19(Suppl 8):861. (PMID: 30537949)
      J Allergy Clin Immunol. 2003 Jan;111(1):117-22. (PMID: 12532106)
      Cytokine. 2015 May;73(1):79-83. (PMID: 25743241)
      Nucleic Acids Res. 2018 Jan 4;46(D1):D267-D275. (PMID: 29126285)
      Am J Hum Genet. 2019 Mar 7;104(3):454-465. (PMID: 30773276)
      Hum Mol Genet. 2017 Feb 1;26(3):501-508. (PMID: 28073928)
      Bioinformatics. 2005 Jan 15;21(2):263-5. (PMID: 15297300)
      Nat Commun. 2018 Jul 30;9(1):2976. (PMID: 30061609)
      J Infect Dis. 2009 Feb 1;199(3):451-4. (PMID: 19099482)
      Am J Hum Genet. 2007 Sep;81(3):559-75. (PMID: 17701901)
      Eur J Immunol. 2012 Oct;42(10):2644-54. (PMID: 22740067)
      PLoS Pathog. 2013;9(8):e1003569. (PMID: 24009502)
    • Accession Number:
      0 (Interleukin-18)
    • Publication Date:
      Date Created: 20191122 Date Completed: 20200218 Latest Revision: 20211204
    • Publication Date:
      20240104
    • Accession Number:
      PMC6894881
    • Accession Number:
      10.1371/journal.pntd.0007859
    • Accession Number:
      31751351