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Effect of cacao polyphenol-rich chocolate on postprandial glycemia, insulin, and incretin secretion in healthy participants.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: United States NLM ID: 8802712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1244 (Electronic) Linking ISSN: 08999007 NLM ISO Abbreviation: Nutrition Subsets: MEDLINE
    • Publication Information:
      Publication: Tarrytown, NY : Elsevier Science
      Original Publication: [Burbank, Calif. : Nutrition, c1987-
    • Subject Terms:
      Cacao* ; Chocolate*; Blood Glucose ; Cross-Over Studies ; Gastric Inhibitory Polypeptide ; Healthy Volunteers ; Humans ; Incretins ; Insulin ; Polyphenols ; Postprandial Period
    • Abstract:
      Objectives: There is substantial interest in using dark chocolate to prevent postprandial hyperglycemia. We investigated the effects of cacao polyphenol-rich chocolate on postprandial glycemic and insulinemic responses and whether cacao polyphenol-rich chocolate increases glucagon-like peptide-1 (GLP-1) secretion.
      Methods: In a stratified, randomized, crossover study, 48 healthy participants ingested either water (W) or cacao polyphenol-rich chocolate plus water (C) 15 min before a 50 g oral glucose tolerance test (OGTT). Pre- and postprandial concentrations of blood glucose, insulin, free fatty acid, glucagon, and GLP-1 were evaluated.
      Results: Peak plasma glucose concentrations did not differ significantly between groups W and C; however, plasma glucose concentrations at 120 min in group C were significantly lower than those in group W (P < .01). Postprandial serum insulin and plasma GLP-1 concentrations and incremental serum insulin and plasma GLP-1 area under the curve (AUC) - 15-180 min for group C were significantly higher than those for group W (P < .05). When comparing the changes after the OGTT, the incremental plasma glucose AUC 0-180 min for group C was significantly lower than that for group W (P < .05), but the incremental serum insulin and plasma GLP-1 AUC 0-180 min did not differ significantly between groups W and C.
      Conclusions: This study indicated that the intake of cacao polyphenol-rich chocolate before a 50 g OGTT could enhance early insulin and GLP-1 secretion in healthy participants, and illustrates the potential of cacao polyphenol-rich chocolate in managing postprandial glucose excursions.
      (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Cacao polyphenol; Chocolate; Glucagon-like peptide-1; Hyperglycemia; Insulin; Postprandial state
    • Accession Number:
      0 (Blood Glucose)
      0 (Incretins)
      0 (Insulin)
      0 (Polyphenols)
      59392-49-3 (Gastric Inhibitory Polypeptide)
    • Publication Date:
      Date Created: 20210205 Date Completed: 20210623 Latest Revision: 20210623
    • Publication Date:
      20240104
    • Accession Number:
      10.1016/j.nut.2020.111128
    • Accession Number:
      33545542