Vitamin D levels in children and adolescents with chronic tic disorders: a multicentre study.

Publisher: Country of Publication: Germany NLM ID: 9212296 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-165X (Electronic) Linking ISSN: 10188827 NLM ISO Abbreviation: Eur Child Adolesc Psychiatry Subsets: MEDLINE

Publication: 2010- : Heidelberg : Springer Medizin
Original Publication: Toronto ; Lewiston, NY : Hogrefe & Huber, [1992-

Tic Disorders*/metabolism ; Tic Disorders*/psychology ; Tics*/complications ; Tics*/metabolism ; Vitamin D*/metabolism; Adolescent ; Attention Deficit Disorder with Hyperactivity/psychology ; Child ; Comorbidity ; Cross-Sectional Studies ; Humans ; Obsessive-Compulsive Disorder/epidemiology ; Obsessive-Compulsive Disorder/psychology ; Severity of Illness Index ; Tourette Syndrome/psychology

This study investigated whether vitamin D is associated with the presence or severity of chronic tic disorders and their psychiatric comorbidities. This cross-sectional study compared serum 25-hydroxyvitamin D [25(OH)D] (ng/ml) levels among three groups: children and adolescents (3-16 years) with CTD (n = 327); first-degree relatives (3-10 years) of individuals with CTD who were assessed for a period of up to 7 years for possible onset of tics and developed tics within this period (n = 31); and first-degree relatives who did not develop tics and were ≥ 10 years old at their last assessment (n = 93). The relationship between 25(OH)D and the presence and severity of tics, as well as comorbid obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD), were analysed controlling for age, sex, season, centre, latitude, family relatedness, and comorbidities. When comparing the CTD cohort to the unaffected cohort, the observed result was contrary to the one expected: a 10 ng/ml increase in 25(OH)D was associated with higher odds of having CTD (OR 2.08, 95% CI 1.27-3.42, p < 0.01). There was no association between 25(OH)D and tic severity. However, a 10 ng/ml increase in 25(OH)D was associated with lower odds of having comorbid ADHD within the CTD cohort (OR 0.55, 95% CI 0.36-0.84, p = 0.01) and was inversely associated with ADHD symptom severity (β = - 2.52, 95% CI - 4.16-0.88, p < 0.01). In conclusion, lower vitamin D levels were not associated with a higher presence or severity of tics but were associated with the presence and severity of comorbid ADHD in children and adolescents with CTD.
(© 2021. The Author(s).)

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278367 Seventh Framework Programme

Investigator: JE Bruun; J Grejsen; CL Ommundsen; M Rubæk; S Enghardt; S Bokemeyer; C Driedger-Garbe; C Reichert; J Schmalfeld; T Duffield; F Gergye; M Kovacs; R Vidomusz; M Carmel; S Fennig; E Gev; N Keller; E Michaelovsky; M Nahon; C Regev; T Simcha; G Smollan; A Weizman; G Gagliardi; M Tallon; P Roazzi; E van den Ban; SFTM de Bruijn; N Driessen; A Lamerz; M Messchendorp; JJG Rath; NSD Sival; N Tromp; F Visscher; SG de la Tourettes; MT Cáceres; F Carrillo; P Gómez-Garre; L Vargas; M Gariup; S Stöber; A Apter; V Baglioni; J Ball; N Benaroya-Milshtein; B Bodmer; M Bond; E Bognar; B Burger; J Buse; F Cardona; MC Vela; A Dietrich; NM Debes; MC Ferro; C Fremer; B Garcia-Delgar; M Gulisano; A Hagen; J Hagstrøm; TJ Hedderly; I Heyman; PJ Hoekstra; C Huyser; M Madruga-Garrido; A Marotta; D Martino; UC Meier; P Mir; N Moll; A Morer; N Mueller; K Müller-Vahl; A Münchau; P Nagy; V Neri; TJC Openneer; A Pellico; ÁP Vasco; KJ Plessen; C Porcelli; M Redondo; R Rizzo; V Roessner; D Ruhrman; JML Schnell; A Schrag; MJ Schwarz; PR Silvestri; L Skov; T Steinberg; FT Gloor; Z Tarnok; J Tübing; VL Turner; S Walitza; E Weidinger; ML Woods
Keywords: ADHD; OCD; Pediatrics; Tic disorder; Tourette; Vitamin D

1406-16-2 (Vitamin D)

Date Created: 20210414 Date Completed: 20220803 Latest Revision: 20220810

20240104

PMC9343310

10.1007/s00787-021-01757-y

33851280