Cocoa Flavanols Adjuvant to an Oral Nutritional Supplement Acutely Enhances Nutritive Flow in Skeletal Muscle without Altering Leg Glucose Uptake Kinetics in Older Adults.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Cacao* ; Dietary Supplements*; Flavonols/*therapeutic use ; Glucose/*metabolism ; Muscle, Skeletal/*drug effects; Aged ; Cross-Over Studies ; Female ; Humans ; Kinetics ; Leg/blood supply ; Male ; Microcirculation/drug effects ; Muscle, Skeletal/metabolism ; Single-Blind Method

Ageing is associated with postprandial muscle vascular and metabolic dysfunction, suggesting vascular modifying interventions may be of benefit. Reflecting this, we investigated the impact of acute cocoa flavanol (450-500 mg) intake (versus placebo control) on vascular (via ultrasound) and glucose/insulin metabolic responses (via arterialised/venous blood samples and ELISA) to an oral nutritional supplement (ONS) in twelve healthy older adults (50% male, 72 ± 4 years), in a crossover design study. The cocoa condition displayed significant increases in m. vastus lateralis microvascular blood volume (MBV) in response to feeding at 180 and 240-min after ONS consumption (baseline: 1.00 vs. 180 min: 1.09 ± 0.03, p = 0.05; 240 min: 1.13 ± 0.04, p = 0.002), with MBV at these timepoints significantly higher than in the control condition ( p < 0.05). In addition, there was a trend ( p = 0.058) for MBV in m. tibialis anterior to increase in response to ONS in the cocoa condition only. Leg blood flow and vascular conductance increased, and vascular resistance decreased in response to ONS ( p < 0.05), but these responses were not different between conditions ( p > 0.05). Similarly, glucose uptake and insulin increased in response to ONS ( p < 0.05) comparably between conditions ( p > 0.05). Thus, acute cocoa flavanol supplementation can potentiate oral feeding-induced increases in MBV in older adults, but this improvement does not relay to muscle glucose uptake.

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MR/P021220/1 United Kingdom MRC_ Medical Research Council; MR/T026014/1 United Kingdom MRC_ Medical Research Council; n/a Abbott Nutrition

Keywords: ageing; blood flow; cocoa flavanols; glucose metabolism; skeletal muscle

0 (Flavonols)
IY9XDZ35W2 (Glucose)

Date Created: 20210602 Date Completed: 20210722 Latest Revision: 20220518

20240104

PMC8152976

10.3390/nu13051646

34068170