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Characteristics and Clinical Course of Adult in Patients with SARS-CoV-2 Pneumonia at High Altitude.

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  • Additional Information
    • Source:
      Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 9433332 Publication Model: eCollection Cited Medium: Internet ISSN: 1916-7245 (Electronic) Linking ISSN: 11982241 NLM ISO Abbreviation: Can Respir J Subsets: MEDLINE
    • Publication Information:
      Publication: <2015- > : Cairo : Hindawi Publishing Corporation
      Original Publication: Oakville, Ont. : Pulsus Group Inc., 1994-
    • Subject Terms:
    • Abstract:
      Background: SARS-CoV-2 has spread worldwide with different dynamics in each region. We aimed to describe the clinical characteristics and to explore risk factors of death, critical care admission, and use of invasive mechanical ventilation in hospitalized patients with SARS-CoV-2 pneumonia in a high-altitude population living in Bogotá, Colombia.
      Methods: We conducted a concurrent cohort study of adult patients with laboratory-confirmed SARS-CoV-2 pneumonia. Demographic, clinical, and treatment data were extracted from electronic records. Univariate and multivariable methods were performed to investigate the relationship between each variable and outcomes at 28 days of follow-up.
      Results: 377 adults (56.8% male) were included in the study, of whom 85 (22.6%) died. Nonsurvivors were older on average than survivors (mean age, 56.7 years [SD 15.8] vs. 70.1 years [SD 13.9]; p ≤ 0.001) and more likely male (28 [32.9%] vs. 57 [67.1%]; p =0.029). Most patients had at least one underlying disease (333 [88.3%]), including arterial hypertension (149 [39.5%]), overweight (145 [38.5%]), obesity (114 [30.2%]), and diabetes mellitus (82 [21.8%]). Frequency of critical care admission (158 [41.9%]) and invasive mechanical ventilation (123 [32.6%]) was high. Age over 65 years (OR 9.26, 95% CI 3.29-26.01; p ≤ 0.001), ICU admission (OR 12.37, 95% CI 6.08-25.18; p ≤ 0.001), and arterial pH higher than 7.47 (OR 0.25, 95% CI 0.08-0.74; p =0.01) were independently associated with in-hospital mortality.
      Conclusions: In this study of in-hospital patients with SARS-CoV-2 pneumonia living at high altitude, frequency of death was similar to what has been reported. ICU admission and use of invasive mechanical ventilation were high. Risk factors as older age, ICU admission, and arterial pH were associated with mortality.
      Competing Interests: The authors declare that they have no conflicts of interest regarding the publication of this article.
      (Copyright © 2021 Javier Leonardo Galindo et al.)
    • References:
      N Engl J Med. 2021 Feb 25;384(8):693-704. (PMID: 32678530)
      Respir Physiol Neurobiol. 2020 Jun;277:103443. (PMID: 32333993)
      J Infect. 2020 Sep;81(3):e96-e98. (PMID: 32474039)
      Rev Clin Esp. 2020 Oct 22;:. (PMID: 33110273)
      Radiology. 2020 Aug;296(2):E97-E104. (PMID: 32339082)
      Nature. 2020 Aug;584(7821):430-436. (PMID: 32640463)
      High Alt Med Biol. 2020 Dec;21(4):409-416. (PMID: 32815745)
      Einstein (Sao Paulo). 2020;18:eAO6022. (PMID: 32813760)
      Front Med (Lausanne). 2020 Aug 14;7:518. (PMID: 32923449)
      Clin Infect Dis. 2020 Nov 19;71(16):2079-2088. (PMID: 32361723)
      N Engl J Med. 2020 Feb 20;382(8):727-733. (PMID: 31978945)
      Res Social Adm Pharm. 2021 Jan;17(1):2036-2039. (PMID: 32265115)
      Travel Med Infect Dis. 2020 May - Jun;35:101667. (PMID: 32289549)
      Int J Infect Dis. 2020 Sep;98:84-89. (PMID: 32553714)
      N Engl J Med. 2020 Apr 30;382(18):1708-1720. (PMID: 32109013)
      JAMA Intern Med. 2020 Aug 1;180(8):1081-1089. (PMID: 32396163)
      JAMA. 2020 May 26;323(20):2052-2059. (PMID: 32320003)
      Lancet. 2020 Mar 28;395(10229):1054-1062. (PMID: 32171076)
      Am J Trop Med Hyg. 2020 Dec;103(6):2347-2349. (PMID: 33124543)
      Epidemiol Serv Saude. 2020 Sep 25;29(4):e2020413. (PMID: 32997070)
      High Alt Med Biol. 2020 Sep;21(3):217-222. (PMID: 32716669)
      Clin Infect Dis. 2020 Sep 12;71(6):1393-1399. (PMID: 32271369)
      High Alt Med Biol. 2020 Dec;21(4):426-427. (PMID: 32803989)
      Arch Bronconeumol (Engl Ed). 2020 Apr;56(4):218-224. (PMID: 31582181)
      Lancet. 2020 Jun 6;395(10239):1763-1770. (PMID: 32442528)
      Lancet. 2020 Oct 3;396(10256):959-967. (PMID: 32896292)
      Chest. 2020 Jul;158(1):97-105. (PMID: 32304772)
      Radiol Cardiothorac Imaging. 2020 Sep 03;2(5):e200280. (PMID: 33778626)
      BMJ. 2020 Sep 9;370:m3339. (PMID: 32907855)
      Eur Respir J. 2020 May 7;55(5):. (PMID: 32269088)
      BMJ. 2020 May 22;369:m1985. (PMID: 32444460)
    • Publication Date:
      Date Created: 20210614 Date Completed: 20210623 Latest Revision: 20210903
    • Publication Date:
      20240105
    • Accession Number:
      PMC8189806
    • Accession Number:
      10.1155/2021/5590879
    • Accession Number:
      34122677