Laboratory Findings in Patients with Probable Dengue Diagnosis from an Endemic Area in Colombia in 2018.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI

COVID-19/*diagnosis ; COVID-19/*epidemiology ; Dengue/*diagnosis; Adolescent ; Adult ; Asia/epidemiology ; Child ; Child, Preschool ; Colombia/epidemiology ; Dengue/virology ; Dengue Virus/isolation & purification ; Diagnostic Tests, Routine/methods ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Infant ; Male ; Pandemics ; Polymerase Chain Reaction ; Reagent Kits, Diagnostic ; SARS-CoV-2/isolation & purification ; Young Adult

As demonstrated with the novel coronavirus pandemic, rapid and accurate diagnosis is key to determine the clinical characteristic of a disease and to improve vaccine development. Once the infected person is identified, hematological findings may be used to predict disease outcome and offer the correct treatment. Rapid and accurate diagnosis and clinical parameters are pivotal to track infections during clinical trials and set protection status. This is also applicable for re-emerging diseases like dengue fever, which causes outbreaks in Asia and Latin America every 4 to 5 years. Some areas in the US are also endemic for the transmission of dengue virus (DENV), the causal agent of dengue fever. However, significant number of DENV infections in rural areas are diagnosed solely by clinical and hematological findings because of the lack of availability of ELISA or PCR-based tests or the infrastructure to implement them in the near future. Rapid diagnostic tests (RDT) are a less sensitive, yet they represent a timely way of detecting DENV infections. The purpose of this study was to determine whether there is an association between hematological findings and the probability for an NS1-based DENV RDT to detect the DENV NS1 antigen. We also aimed to describe the hematological parameters that are associated with the diagnosis through each test.

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PROMIS ID P00144_20_N6_02, 2019-2020 U.S. Department of Defense

Keywords: PCR; dengue virus; hemogram; rapid diagnosis

0 (Reagent Kits, Diagnostic)

Date Created: 20210810 Date Completed: 20210823 Latest Revision: 20210823

20240105

PMC8310201

10.3390/v13071401

34372606