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Recombination events drives the emergence of Colombian Helicobacter pylori subpopulations with self-identity ancestry.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101531386 Publication Model: Print Cited Medium: Internet ISSN: 2150-5608 (Electronic) Linking ISSN: 21505594 NLM ISO Abbreviation: Virulence Subsets: MEDLINE
    • Publication Information:
      Publication: 2015- : Philadelphia, PA : Taylor & Francis
      Original Publication: Austin, Tex. : Landes Bioscience
    • Subject Terms:
    • Abstract:
      Helicobacter pylori have coevolved with mankind since its origins, adapting to different human groups. In America, H. pylori has evolved into several subpopulations. We analysed the genome of 154 Colombian strains along with 1,091 strains from worldwide populations to discern the ancestry and adaption to Colombian people. Population structure and ancestry was inferred with FineStructure and ChromoPainter. Phylogenetic relationship and the relative effect of recombination were analysing the core SNPs. Also, a Fst index was calculated to identify the gene variants with the strongest fixation in the Colombian subpopulations compared to their parent population hspSWEurope . FineStructure allowed the identification of two Colombian subpopulations, the previously described hspSWEuropeColombia and a novel subpopulation named hspColombia , that included three subgroups following their geographic origin. Colombian subpopulations represent an admixture of European, African and Indigenous ancestry; although some genomes showed a high proportion of self identity, suggesting an advanced adaption to these mestizo Colombian groups. We found that recombination is more important that punctual mutations in H. pylori genome diversity, 13.9 more important in hspSWEurope , 12.5 in hspSWEColombia and 10.5 in hspColombia , reflecting the divergence of these subpopulations. Fst analysis identified 82 SNPs fixed in 26 genes of the hspColombia subpopulation that encode for outer membrane and central metabolism proteins. Strongest fixation indexes were identified in genes encoding HofC, HopE, FrpB-4 and Sialidase A. These findings demonstrate that H. pylori has evolved in Colombia to give rise to subpopulations with a self identity ancestry, reflected in allele changes on genes encoding for outer membrane proteins.
    • References:
      Mol Biol Evol. 2018 Jun 1;35(6):1547-1549. (PMID: 29722887)
      Gut. 2011 Sep;60(9):1189-95. (PMID: 21357593)
      PLoS One. 2016 Oct 13;11(10):e0164414. (PMID: 27736937)
      World J Gastroenterol. 2017 Feb 7;23(5):800-809. (PMID: 28223724)
      Mol Microbiol. 2018 Mar;107(6):676-687. (PMID: 29315884)
      PLoS Genet. 2017 Feb 23;13(2):e1006546. (PMID: 28231283)
      PLoS One. 2010 Nov 29;5(11):e15076. (PMID: 21124785)
      Front Genet. 2014 Aug 25;5:290. (PMID: 25202324)
      Forensic Sci Int Genet. 2021 Jul;53:102495. (PMID: 33743518)
      Front Cell Infect Microbiol. 2017 Feb 28;7:50. (PMID: 28293542)
      PLoS One. 2010 Mar 10;5(3):e9490. (PMID: 20224823)
      PLoS Comput Biol. 2015 Feb 12;11(2):e1004041. (PMID: 25675341)
      Front Microbiol. 2020 Dec 14;11:601839. (PMID: 33381095)
      J Comput Chem. 2004 Oct;25(13):1605-12. (PMID: 15264254)
      Evol Appl. 2019 Sep 18;13(2):278-289. (PMID: 31993076)
      Trends Microbiol. 1999 May;7(5):182-4. (PMID: 10383222)
      World J Gastroenterol. 2010 Jan 21;16(3):320-9. (PMID: 20082477)
      Nature. 1997 Aug 7;388(6642):539-47. (PMID: 9252185)
      Mol Biol Evol. 2013 Jun;30(6):1454-64. (PMID: 23505045)
      ISME J. 2021 Jan;15(1):78-92. (PMID: 32879462)
      Nucleic Acids Res. 2019 Jul 2;47(W1):W256-W259. (PMID: 30931475)
      Bioinformatics. 2011 Aug 1;27(15):2156-8. (PMID: 21653522)
      Genome Res. 2004 Jun;14(6):1188-90. (PMID: 15173120)
      Microb Genom. 2022 Feb;8(2):. (PMID: 35188454)
      PLoS Genet. 2012 Jan;8(1):e1002453. (PMID: 22291602)
      Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1455-60. (PMID: 24474772)
      Science. 2015 Aug 21;349(6250):aab3884. (PMID: 26198033)
      Bioinformatics. 2014 Jul 15;30(14):2068-9. (PMID: 24642063)
      Nucleic Acids Res. 2004 Mar 19;32(5):1792-7. (PMID: 15034147)
      Nature. 2007 Feb 22;445(7130):915-918. (PMID: 17287725)
      PLoS One. 2014 Aug 14;9(8):e105392. (PMID: 25121764)
      Gut Pathog. 2017 Sep 11;9:52. (PMID: 28912838)
    • Grant Information:
      P30 CA093373 United States CA NCI NIH HHS; R01 CA223978 United States CA NCI NIH HHS
    • Contributed Indexing:
      Keywords: Colombia; Helicobacter pylori; ancestry; evolution; population structure; recombination
    • Publication Date:
      Date Created: 20220715 Date Completed: 20220718 Latest Revision: 20220809
    • Publication Date:
      20240104
    • Accession Number:
      PMC9291697
    • Accession Number:
      10.1080/21505594.2022.2095737
    • Accession Number:
      35838227