Urge-tic associations in children and adolescents with Tourette syndrome.

Item request has been placed!

Item request cannot be made.

Processing Request

Read Online Read More Add to Saved list

Author(s): Langelage J;Langelage J; Verrel J; Verrel J; Friedrich J; Friedrich J; Siekmann A; Siekmann A; Schappert R; Schappert R; Bluschke A; Bluschke A; Roessner V; Roessner V; Paulus T; Paulus T; Paulus T; Bäumer T; Bäumer T; Frings C; Frings C; Beste C; Beste C; Münchau A; Münchau A
Source:
Scientific reports [Sci Rep] 2022 Sep 26; Vol. 12 (1), pp. 16008. Date of Electronic Publication: 2022 Sep 26.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
English

Additional Information
- Source:
  Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
- Publication Information:
  Original Publication: London : Nature Publishing Group, copyright 2011-
- Subject Terms:
  Tic Disorders* ; Tics* ; Tourette Syndrome*/complications; Adolescent ; Adult ; Child ; Emotions ; Humans ; Severity of Illness Index
- Abstract:
  Premonitory urges preceding tics are a cardinal feature of Gilles de la Tourette syndrome (GTS), a developmental disorder usually starting during middle childhood. However, the temporal relation between urges and tics has only been investigated in adults. In 25 children and adolescents with GTS (8-18 years), we assess urge-tic associations, including inter-individual differences, correlation to clinical measures, and in comparison to a previously reported sample of adult GTS patients. Group-level analyses confirmed positive associations between urges and tics. However, at the individual level, less than half of participants showed positive associations, a similar proportion did not, and in two participants, the association was reversed. Tic expression and subjective urge levels correlated with corresponding clinical scores and participants with more severe tics during the urge monitor exhibited stronger urge-tic associations. Associations between reported urge levels and instantaneous tic intensity tended to be less pronounced in children and adolescents than in adult GTS patients. The observed heterogeneity of urge-tic associations cast doubt on the notion that tics are directly caused by urges. More severe tics may facilitate anticipation of tics and thereby lead to more pronounced urge-tic associations, consistent with a hypothesis of urges as a byproduct of tics.
  (© 2022. The Author(s).)
- References:
  Curr Opin Neurobiol. 2017 Oct;46:187-199. (PMID: 29017141)
  Trends Cogn Sci. 2015 Nov;19(11):655-665. (PMID: 26440120)
  Pediatrics. 1998 Jul;102(1 Pt 1):14-9. (PMID: 9651407)
  Front Psychol. 2013 Jun 05;4:328. (PMID: 23761778)
  J Clin Psychiatry. 1995 Jun;56(6):246-55. (PMID: 7775367)
  Dev Med Child Neurol. 2000 Jul;42(7):436-47. (PMID: 10972415)
  Brain. 2006 Aug;129(Pt 8):2029-37. (PMID: 16520330)
  Behav Res Ther. 2007 Dec;45(12):2964-76. (PMID: 17854764)
  Am J Psychiatry. 1993 Jan;150(1):98-102. (PMID: 8417589)
  Parkinsonism Relat Disord. 2019 Aug;65:153-158. (PMID: 31182372)
  Neuropsychologia. 2014 Dec;65:297-301. (PMID: 25128587)
  J Psychosom Res. 2009 Dec;67(6):497-501. (PMID: 19913654)
  Front Psychiatry. 2020 Sep 29;11:519931. (PMID: 33132927)
  J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57. (PMID: 9881538)
  Behav Res Methods. 2019 Feb;51(1):195-203. (PMID: 30734206)
  Behav Res Ther. 2015 Jul;70:56-63. (PMID: 25988365)
  Mov Disord. 2010 Jun 15;25(8):1106-8. (PMID: 20535828)
  Front Neurosci. 2016 Sep 12;10:415. (PMID: 27672357)
  Cortex. 2021 Oct;143:80-91. (PMID: 34391084)
  J Neurol Neurosurg Psychiatry. 2012 Oct;83(10):975-8. (PMID: 22842713)
  Brain. 2000 Mar;123 Pt 3:425-62. (PMID: 10686169)
  Dev Med Child Neurol. 2009 Mar;51(3):218-27. (PMID: 19183216)
  Curr Dev Disord Rep. 2014 Dec;1(4):245-251. (PMID: 25844305)
  J Clin Psychiatry. 2010 Mar;71(3):313-26. (PMID: 20331933)
  Arch Pediatr Adolesc Med. 2006 Jan;160(1):65-9. (PMID: 16389213)
  Neurosci Biobehav Rev. 2013 Jul;37(6):997-1007. (PMID: 23206664)
  Dev Med Child Neurol. 2003 Oct;45(10):700-3. (PMID: 14515942)
  J Dev Behav Pediatr. 2005 Dec;26(6):397-403. (PMID: 16344654)
  Behav Modif. 2014 Mar;38(2):276-96. (PMID: 24752420)
  JAMA. 2010 May 19;303(19):1929-37. (PMID: 20483969)
  Mov Disord. 2022 Mar;37(3):563-573. (PMID: 34854494)
  Cortex. 2016 Apr;77:24-37. (PMID: 26922503)
  Lancet. 2002 Nov 16;360(9345):1577-86. (PMID: 12443611)
  Arch Clin Neuropsychol. 2007 Nov;22(8):917-24. (PMID: 17662573)
  Curr Treat Options Neurol. 2013 Aug;15(4):385-95. (PMID: 23645295)
  JAMA Psychiatry. 2015 Apr;72(4):325-33. (PMID: 25671412)
  Behav Res Ther. 2011 Aug;49(8):492-7. (PMID: 21658680)
  J Am Acad Child Adolesc Psychiatry. 1989 Jul;28(4):566-73. (PMID: 2768151)
  J Neural Transm (Vienna). 2018 Apr;125(4):727-734. (PMID: 29185077)
  Cortex. 2016 Apr;77:132-140. (PMID: 26963083)
  Am J Psychiatry. 2011 Dec;168(12):1326-37. (PMID: 21955933)
  Front Psychiatry. 2016 Apr 07;7:51. (PMID: 27092085)
  J Neuropsychiatry Clin Neurosci. 2017 Spring;29(2):95-104. (PMID: 28121259)
  Mov Disord. 2015 Aug;30(9):1190-7. (PMID: 25855089)
  Brain. 2009 Jan;132(Pt 1):225-38. (PMID: 18952678)
- Publication Date:
  Date Created: 20220927 Date Completed: 20220928 Latest Revision: 20221125
- Publication Date:
  20240105
- Accession Number:
  PMC9512906
- Accession Number:
  10.1038/s41598-022-19685-5
- Accession Number:
  36163482

Comments

No Comments.