Integrative analysis of gene and protein expression in atherosclerosis-related pathways modulated by periodontal pathogens. Systematic review.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101481371 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1882-7616 (Print) Linking ISSN: 18827616 NLM ISO Abbreviation: Jpn Dent Sci Rev Subsets: PubMed not MEDLINE

Original Publication: Amsterdam ; London : Elsevier, 2008-

The mechanisms modulated by periodontal pathogens in atherosclerosis are not fully understood. Aim: to perform an integrative analysis of gene and protein expression modulated by periodontal pathogens in cells and animal models for atherosclerosis.
Methods: Cochrane, PRISMA and AMSTAR2 guidelines for systematic reviews were followed. Data search was conducted in Pub-med, LILACS and Science Direct databases. Gene and protein expression data were collected from the included papers to perform an overrepresentation analysis using the Reactome Pathway Analysis tool and the KEGG database.
Results: Thirty-two papers were included in the review, they analyzed the effect of Fusobacterium nucleatum , Porphyromonas gingivalis , Streptococcus anginosus , Streptococcus sanguinis , Tannerella forsythia , and Treponema denticola or/and their virulent factors on gene and protein expression in human cells and animal models of atherosclerosis. Some of the modulated pathways include the immune system, programmed cell death, cellular responses to external stimuli, transport of small molecules, and signal transduction (p < 0.05). Those pathways are known to be involved in different stages of atherosclerosis progression.
Conclusion: Based on the performed analysis, it is possible to state that periodontal pathogens have the potential to be a contributing factor for atherosclerosis even in absence of a high-fat diet or high shear stress.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 Japanese Association for Dental Science.)

Inflammation. 2019 Jun;42(3):874-883. (PMID: 30506423)
PLoS One. 2015 May 04;10(5):e0125126. (PMID: 25938460)
Pathog Dis. 2018 Nov 1;76(8):. (PMID: 30351354)
Community Dent Oral Epidemiol. 2018 Dec;46(6):615-623. (PMID: 30160305)
Infect Immun. 2015 Dec;83(12):4582-93. (PMID: 26371120)
Cells. 2021 Jan 25;10(2):. (PMID: 33503867)
Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1492-1500. (PMID: 31018659)
Innate Immun. 2015 Jan;21(1):65-72. (PMID: 24583910)
Circulation. 2012 May 22;125(20):2520-44. (PMID: 22514251)
Nat Med. 2011 Nov 07;17(11):1410-22. (PMID: 22064431)
BMC Microbiol. 2018 Feb 26;18(1):16. (PMID: 29482504)
APMIS. 2017 Jul;125(7):623-633. (PMID: 28493507)
Mediators Inflamm. 2015;2015:364391. (PMID: 26063970)
Protein Sci. 2022 Jan;31(1):47-53. (PMID: 34423492)
J Oral Maxillofac Pathol. 2019 Jan-Apr;23(1):122-128. (PMID: 31110428)
Int J Mol Sci. 2021 Apr 08;22(8):. (PMID: 33917744)
Clin Lab. 2017 Oct 1;63(10):1627-1637. (PMID: 29035447)
Biomedicines. 2021 Jul 06;9(7):. (PMID: 34356845)
Postgrad Med J. 2017 Apr;93(1098):215-220. (PMID: 27899684)
Biochem Biophys Res Commun. 2019 Dec 10;520(3):507-513. (PMID: 31610917)
Pathog Dis. 2015 Apr;73(3):. (PMID: 25663343)
Cell Metab. 2005 Feb;1(2):121-31. (PMID: 16054053)
BMJ. 2021 Mar 29;372:n71. (PMID: 33782057)
Front Cell Dev Biol. 2020 Jul 14;8:596. (PMID: 32793587)
Infect Immun. 2015 Nov;83(11):4256-65. (PMID: 26283334)
Pathog Dis. 2015 Jun;73(4):. (PMID: 25663345)
J Periodontal Implant Sci. 2018 Feb 27;48(1):60-68. (PMID: 29535891)
Mol Oral Microbiol. 2015 Oct;30(5):399-410. (PMID: 25939768)
J Periodontal Res. 2015 Jun;50(3):356-62. (PMID: 25065326)
NPJ Biofilms Microbiomes. 2016 Dec 19;2:7. (PMID: 28649401)
PLoS One. 2015 Jun 16;10(6):e0129795. (PMID: 26079509)
Int J Mol Sci. 2018 Jul 06;19(7):. (PMID: 29986441)
Arch Med Sci. 2016 Oct 1;12(5):959-967. (PMID: 27695485)
J Periodontol. 2016 Jul;87(7):828-36. (PMID: 26991490)
J Gen Intern Med. 2008 Dec;23(12):2079-86. (PMID: 18807098)
BMJ. 2017 Sep 21;358:j4008. (PMID: 28935701)
N Engl J Med. 1999 Jan 14;340(2):115-26. (PMID: 9887164)
Physiol Rep. 2019 Apr;7(7):e14069. (PMID: 30980509)
Trials. 2010 Mar 24;11:32. (PMID: 20334632)
Vascul Pharmacol. 2018 Jul;106:1-8. (PMID: 29471141)
J Periodontol. 2014 Dec;85(12):1648-57. (PMID: 25019176)
Circ Res. 2020 Mar 13;126(6):e15-e29. (PMID: 32078488)
Nucleic Acids Res. 2020 Jan 8;48(D1):D498-D503. (PMID: 31691815)
Atherosclerosis. 2021 Aug;330:95-106. (PMID: 34247863)
Cochrane Database Syst Rev. 2019 Oct 3;10:ED000142. (PMID: 31643080)
Int J Cardiol. 2015 Dec 15;201:469-72. (PMID: 26313869)
PLoS One. 2015 Nov 30;10(11):e0143291. (PMID: 26619277)
Arch Cardiovasc Dis. 2016 Dec;109(12):708-715. (PMID: 27595467)
Nature. 2000 Sep 14;407(6801):233-41. (PMID: 11001066)
Sci Rep. 2016 Feb 24;6:21911. (PMID: 26907358)
Hamostaseologie. 2014;34(1):63-71. (PMID: 24343521)
Am J Transl Res. 2016 Feb 15;8(2):384-404. (PMID: 27158334)
Int J Oral Sci. 2019 Jul 1;11(3):21. (PMID: 31257363)
Nat Med. 2015 Jul;21(7):677-87. (PMID: 26121197)
Eur J Oral Sci. 2018 Dec;126(6):476-484. (PMID: 30357941)
Nat Protoc. 2019 Mar;14(3):703-721. (PMID: 30804569)
Mediators Inflamm. 2018 Jul 29;2018:1967506. (PMID: 30150893)
J Periodontol. 2021 Aug;92(8):1079-1087. (PMID: 34152022)
J Cell Mol Med. 2020 Jul;24(14):7979-7990. (PMID: 32462812)
ScientificWorldJournal. 2020 May 28;2020:2146160. (PMID: 32549797)
Periodontol 2000. 2020 Jun;83(1):66-89. (PMID: 32385870)
Saudi J Anaesth. 2019 Apr;13(Suppl 1):S31-S34. (PMID: 30930717)
Mol Oral Microbiol. 2017 Jun;32(3):211-225. (PMID: 27224005)
Arch Immunol Ther Exp (Warsz). 2013 Feb;61(1):1-14. (PMID: 23224338)
Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489. (PMID: 33237286)
Nucleic Acids Res. 2000 Jan 1;28(1):27-30. (PMID: 10592173)
PLoS One. 2017 Feb 24;12(2):e0172773. (PMID: 28235036)
Am Heart J. 2007 Nov;154(5):830-7. (PMID: 17967586)
FEBS Open Bio. 2016 Nov 21;6(12):1310-1319. (PMID: 28255538)
Biomed Res Int. 2015;2015:825397. (PMID: 26504835)

Keywords: Atherosclerosis; Bacteria; Metagenomics; Microorganisms; Molecular; Periodontal pathogens; Periodontitis

Date Created: 20230119 Latest Revision: 20230120

20240104

PMC9841036

10.1016/j.jdsr.2022.12.001

36654677