Abstract: Introduction: Streptococcus pneumoniae serotype 3 is an important cause of pneumonia, bacteremia, and meningitis.Objective: To establish the circulating genotypes of S. pneumoniae serotype 3 isolates recovered from the invasive disease between 1994 to 2015 in Colombia.Materials and methods: Of the 365 S. pneumoniae serotype 3 isolates recovered through the laboratory national surveillance program, 117 isolates were analyzed. Pulsed-field gel electrophoresis was used for genotyping, and multilocus sequence typing was determined in representative isolates.Results: The frequency of this serotype increased from 2.7% between 1994 and 1998 to 9.1% between 2011 and 2015 (p=0.000); 91.7% of the isolates showed a genetic similarity greater than 77% and were related to the Netherlands3-31(PMEN31) clone CC180. Several subtypes were identified, two of which showed antimicrobial resistance.Conclusion: In Colombia, the pneumococcal population of the capsular type 3 shows a continuous and homogeneous circulation relating to the clonal group ST-180. ; Introducción. El serotipo 3 de Streptococcus pneumoniae es una causa importante de neumonía, bacteriemia y meningitis.Objetivo. Establecer los genotipos circulantes de aislamientos del serotipo 3 de S. pneumoniae recuperados de muestras de enfermedad invasiva de 1994 a 2015 en Colombia.Materiales y métodos. Se analizaron 117 de los 365 aislamientos del serotipo 3 de S. pneumoniae recuperados del programa nacional de vigilancia por el laboratorio. El genotipo se estableció con electroforesis en gel de campo pulsado y la tipificación se llevó a cabo mediante secuenciación multilocus en aislamientos representativos.Resultados. La frecuencia de este serotipo aumentó de 2,7 % entre 1994 y 1998 a 9,1 % entre 2011 y 2015 (p=0,000). El 91,7 % de los aislamientos evidenció una similitud genética superior al 77 % y se relacionó con el clon CC180 de Netherlands3-31 (PMEN31). Se identificaron varios subtipos, dos de los cuales mostraron resistencia a los antimicrobianos.Conclusión. En ...
Relation: https://revistabiomedica.org/index.php/biomedica/article/view/5407/4786; https://revistabiomedica.org/index.php/biomedica/article/view/5407/4855; https://revistabiomedica.org/index.php/biomedica/article/view/5407/4913; Balsells E, Guillot L, Nair H, Kyaw MH. Serotype distribution of Streptococcus pneumoniae causing invasive disease in children in the post-PCV era: A systematic review and metaanalysis. PLoS ONE. 2017;12:1-20.; Wahl B, O’Brien KL, Greenbaum A, Majumder A, Liu L, Chu Y, et al. Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: Global, regional, and national estimates for 2000-15. Lancet Glob Health. 2018;6:e744-57.; Geno KA, Gilbert GL, Song JY, Skovsted IC, Klugman KP, Jones C, et al. Pneumococcal capsules and their types: Past, present, and future. Clin Microbiol Rev. 2015;28:871-99.; McAllister LJ, Ogunniyi AD, Stroeher UH, Leach AJ, Paton JC. Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates. Infect Immun. 2011;79:4839-49.; Hausdorff WP, Feikin DR, Klugman KP. Epidemiological differences among pneumococcal serotypes. Lancet Infect Dis. 2005;5:83-93.; Mcgee L, Mcdougal L, Zhou J, Spratt BG, Tenover FC, George R, et al. Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network. J Clin Microbiol. 2001;39:2565-71.; Croucher NJ, Mitchell AM, Gould KA, Inverarity D, Barquist L, Feltwell T, et al. Dominant role of nucleotide substitution in the diversification of serotype 3 pneumococci over decades and during a single infection. PLoS Genet. 2013;9:e1003868. https://doi.org/10.1371/journal.pgen.1003868; Isozumi R, Ito Y, Ishida T, Hirai T, Ito I, Maniwa K, et al. Molecular characteristics of serotype 3 Streptococcus pneumoniae isolates among community-acquired pneumonia patients in Japan. J Infect Chemother. 2008;14:258-61.; Slotved HC, Dalby T, Hoffmann S. Multilocus sequence types of invasive pneumococcal isolates from Danish infants (0-90 days) 2003-2013. BMC research notes. 2015;8:1-4.; Beall B, McEllistrem MC, Gertz RE, Wedel S, Boxrud DJ, González AL, et al. Pre- and postvaccination clonal compositions of invasive pneumococcal serotypes for isolates collected in the United States in 1999, 2001, and 2002. J Clin Microbiol. 2006;44:999-1017.; Caierão J, Hawkins P, Sant’anna FH, Da Cunha GR, D’Azevedo PA, McGee L, et al. Serotypes and genotypes of invasive Streptococcus pneumoniae before and after PCV10 implementation in southern Brazil. PLoS ONE. 2014;9:e111129. https://doi.org/10.1371/journal.pone.0111129; Mothibeli KM, Du Plessis M, von Gottberg A, De Gouveia L, Adrian P, Madhi SA, et al. An unusual pneumococcal sequence type is the predominant cause of serotype 3 invasive disease in South Africa. J Clin Microbiol. 2010;48:184-91.; Di Fabio JL, Homma A, De Quadros C. Pan American Health Organization epidemiological surveillance network for Streptococcus pneumoniae. Microb Drug Resist. 1997;3:131-3.; Pan American Health Organization. Regional Report of SIREVA II, 2009. Data by country and by age groups on the characteristics of the isolates of Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis, in bacterial invasive processes. Washington D.C.; 2010. http://bit.do/InfoSIREVA2009; Instituto Nacional de Salud. Laboratory surveillance of invasive isolates of Streptococcus pneumoniae Colombia 2006-2017 Directorate Networks in Public Health Sub directorate National Reference Laboratory Microbiology Group. Bogotá; 2018. www.ins.gov.co/buscadoreven-tos/Informacin de laboratorio/VigilanciaporLaboratoriodeS.pneumoniae2006-2017.pdf; Parra EL, Ramos V, Sanabria O, Moreno J. Serotype and genotype distribution among invasive Streptococcus pneumoniae isolates in Colombia, 2005-2010. PLoS ONE. 2014;9:2005-10.; Castañeda-Orjuela C, Hoz-Restrepo FD la. How cost effective is switching universal vaccination from PCV10 to PCV13? A case study from a developing country. Vaccine. 36:5766-73. https://doi.org/10.1016/j.vaccine.2018.07.078; Clinical Laboratory Standards Institute. M100-S25 Performance Standards for Antimicrobial. Susceptibility Testing; Twenty-Fifth Informational Supplement, PA: Clinical Laboratory Standards Institute. 2015;35:84-8; Vela MC, Fonseca N, Fabio JL di, Castañeda E. Presence of international multiresistant clones of Streptococcus pneumoniae in Colombia. Microb Drug Resist. 2001;7:153-64.; Enright MC, Spratt BG. A multilocus sequence typing scheme for Streptococcus pneumoniae: Identification of clones associated with serious invasive disease. Microbiology. 1998;144:3049-60.; Pan American Health Organization. Regional Report of SIREVA II, 2000-2015. Data by country and by age groups on the characteristics of the isolates of Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis, in bacterial invasive processes. 2018. http://bit.do/InfoSIREVA2000-2015; Bardach AE, Rey-Ares L, Calderón-Cahua M, Ciapponi A, Cafferata ML, Cormick G, et al. Burden of culture-confirmed pediatric pneumococcal pneumonia in Latin America and the Caribbean: A systematic review and meta-analysis. Value Health Reg Issues. 2017;14:41-52. https://doi.org/10.1016/j.vhri.2017.04.004; Moore MR, Link-Gelles R, Schaffner W, Lynfield R, Lexau C, Bennett NM, et al. Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: Analysis of multisite, population-based surveillance. Lancet Infect Dis. 2015;15:301-9.; Nieddu F, Moriondo M, De Vitis E, Ricci S, Indolfi G, Resti M, et al. PCV13 serotype decrease in Italian adolescents and adults in the post-PCV13 era: Herd protection from children or secular trend? Vaccine. 2017;35:154450. https://doi.org/10.1016/j.vaccine.2017.01.064; Guevara M, Ezpeleta C, Gil-Setas A, Torroba L, Beristain X, Aguinaga A, et al. Reduced incidence of invasive pneumococcal disease after introduction of the 13-valent conjugate vaccine in Navarre, Spain, 2001-2013. Vaccine. 2014;32:2553-62.; Shoji H, Maeda M, Takuma T, Niki Y. Serotype distribution of Streptococcus pneumoniae isolated from adult respiratory tract infections in nationwide Japanese surveillances from 2006 to 2014. J Infect Chemother. 2017;23:538-44. https://doi.org/10.1016/j.jiac.2017.05.003; Grabenstein JD, Musey LK. Differences in serious clinical outcomes of infection caused by specific pneumococcal serotypes among adults. Vaccine. 2014;32:2399-405.; Syrogiannopoulos GA, Michoula AN, Tsimitselis G, Vassiou K, Chryssanthopoulou DC, Grivea IN. Pneumonia with empyema among children in the first five years of high coverage with 13-valent pneumococcal conjugate vaccine. Infect Dis (Lond.) 2016;48:74953.; Fletcher MA, Schmitt HJ, Syrochkina M, Sylvester G. Pneumococcal empyema and complicated pneumonias: Global trends in incidence, prevalence, and serotype epidemiology. Eur J Clin Microbiol Infect Dis. 2014;33:879-910.; Silva-Costa C, Brito MJ, Pinho MD, Friães A, Aguiar SI, Ramírez M, et al. Pediatric complicated pneumonia caused by Streptococcus pneumoniae serotype 3 in 13-valent pneumococcal conjugate vaccinees, Portugal, 2010-2015. Emerg Infect Dis. 2018;24:1307-14.; Feldman C, Anderson R. Pneumonia as a systemic illness. Curr Op Pulm Med. 2018;24:237-43.; Garcia-Vidal C, Ardanuy C, Tubau F, Viasus D, Dorca J, Liñares J, et al. Pneumococcal pneumonia presenting with septic shock: Host- and pathogen-related factors and outcomes. Thorax. 2010;65:77-81.; Barcus VA, Ghanekar K, Yeo M, Coffey TJ, Dowson CG. Genetics of high level penicillin resistance in clinical isolates of Streptococcus pneumoniae. FEMS Microbiol Lett. 1995;126:299-303.; Ubukata K, Chiba N, Hanada S, Morozumi M, Wajima T, Shouji M, et al. Serotype changes and drug resistance in invasive pneumococcal diseases in adults after vaccinations in children, Japan, 2010-2013. Emerg Infect Dis. 2015;21:1956-65.; Chiba N, Murayama SY, Morozumi M, Iwata S, Ubukata K. Genome evolution to penicillin resistance in serotype 3 Streptococcus pneumoniae by capsular switching. Antimicrob Agents Chemother. 2017;61:1-6.; Ramos V, Duarte C, Díaz A, Moreno J. Mobile genetic elements associated with erythromycin resistance in Streptococcus pneumoniae isolates in Colombia. Biomédica. 2014;34:209-16.; Mingoia M, Tili E, Manso E, Varaldo PE, Montanari MP. Heterogeneity of Tn5253-like composite elements in clinical Streptococcus pneumoniae isolates. Antimicrob Agents Chemother. 2011;55:1453-9.; Echániz-Aviles G, Guerreiro SI, Silva-Costa C, Mendes CI, Carriço JA, Carnalla-Barajas MN, et al. Streptococcus pneumoniae serotype 3 in México (1994 to 2017): Decrease of the unusual clonal complex 4909 Lineage following PCV13 introduction. J Clin Microbiol. 2019;57:e01354-18. https://doi.org/10.1128/JCM.01354-18; Domenech A, Ardanuy C, Calatayud L, Santos S, Tubau F, Grau I, et al. Serotypes and genotypes of Streptococcus pneumoniae causing pneumonia and acute exacerbations in patients with chronic obstructive pulmonary disease. J Antimicrob Chemother. 2011;66:487-93.; Azarian T, Mitchell PK, Georgieva M, Thompson CM, Ghouila A, Pollard AJ, et al. Global emergence and population dynamics of divergent serotype 3 CC180 pneumococci. PLoS Pathog. 2018;14:e1007438. https://doi.org/10.1371/journal.ppat.1007438; Gladstone RA, Lo SW, Lees JA, Croucher NJ, van Tonder AJ, Corander J, et al. International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact. EBioMedicine. 2019;43:338-46. https://doi.org/10.1016/j.ebiom.2019.04.021; https://revistabiomedica.org/index.php/biomedica/article/view/5407
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