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Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3‐O‐Sulfate (GCDCA‐S) as Endogenous Biomarker of OATP1B3 and OAT3 Transporters

• Authors : Ujihira, Yuki; Georgiev, Viktor; Ogungbenro, Kayode

• Source: Ujihira, Y, Georgiev, V, Ogungbenro, K & Galetin, A 2025, 'Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3‐O‐Sulfate (GCDCA‐S) as Endogenous Biomarker of OATP1B3 and OAT3

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Predicting OCT2/MATEs-Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

• Authors : Asano, Satoshi; Galetin, Aleksandra; Tomita, Yoshiko

• Source: Asano, S, Galetin, A, Tomita, Y, Giacomini, K M, Chu, X, Yang, X, Nakamura, T, Kusuhara, H & Sugiyama, Y 2025, 'Predicting OCT2/MATEs-Mediated Drug Interactions in Healthy Volunteers and Patients with

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Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data

• Authors : Cleary, Yumi; Milani, Nicolo; Ogungbenro, Kayode

• Source: Cleary, Y, Milani, N, Ogungbenro, K, Aarons, L, Galetin, A & Gertz, M 2025, 'Simultaneous Estimation of fm and FG Values Directly from Clinical Drug-Drug Interaction Study Data', The AAPS journal,

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Evaluation of Adefovir PBPK Model to Assess Biomarker‐Informed OAT1 Drug–Drug Interaction and Effect of Chronic Kidney Disease

• Authors : Tan, Shawn Pei Feng; Wu, Huaying; Rostami‐Hodjegan, Amin

Subjects: Organic Anion Transporters; Endogenous Biomarker; Chronic Kidney Disease

• Source: Tan, S P F, Wu, H, Rostami‐Hodjegan, A, Scotcher, D & Galetin, A 2025, 'Evaluation of Adefovir PBPK Model to Assess Biomarker‐Informed OAT1 Drug–Drug Interaction and Effect of Chronic Kidney

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Establishing a physiologically-based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates

• Authors : Izat, Nihan; Bolleddula , Jayaprakasam; Carione, Pasquale

• Source: Izat, N, Bolleddula , J, Carione, P, Huertas Valentin, L, Jones, R S, Kulkarni, P, Moss, D, Peterkin, V C, Tian, D-D, Treyer, A, Venkatakrishnan, K, Zientek, M A, Barber, J, Houston, J, Galetin, A &

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Evaluating drug-drug interaction risk associated with peptide analogues using advanced in vitro systems

• Authors : Nørgaard, Rune Aa; Bhatt, Deepak K; Järvinen, Erkka

• Source: Nørgaard, R A, Bhatt, D K, Järvinen, E, Stage, T B, Gabel-Jensen, C, Galetin, A & Säll, C 2024, 'Evaluating drug-drug interaction risk associated with peptide analogues using advanced in vitro

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Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker- Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease

• Authors : Tan, Shawn pei feng; Willemin, Marie‐emilie; Snoeys, Jan

Subjects: Drug-drug interaction; Endogenous Biomarker; Chronic Kidney Disease

• Source: Tan, S P F, Willemin, M, Snoeys, J, Shen, H, Rostami‐hodjegan, A, Scotcher, D & Galetin, A 2023, 'Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker- Informed Evaluation of OAT1/3

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Drug-drug interaction database for safe prescribing of systemic antifungal agents

• Authors : Niazi-Ali, Saarah; Atherton, Graham T; Walczak, Marcin

• Source: Niazi-Ali, S, Atherton, G T, Walczak, M & Denning, D W 2021, 'Drug-drug interaction database for safe prescribing of systemic antifungal agents', Therapeutic advances in infectious disease, vol. 8,

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Model-Based Drug-Drug Interaction Extrapolation Strategy From Adults to Children:Risdiplam in Pediatric Patients With Spinal Muscular Atrophy

• Authors : Fukushima (Cleary), Yumi; Gertz, Michael; Grimsey, Paul

Subjects: Adolescent; Adult; Azo Compounds/pharmacokinetics

• Source: Fukushima (Cleary), Y, Gertz, M, Grimsey, P, Günther, A, Heinig, K, Ogungbenro, K, Aarons, L, Galetin, A & Kletzl, H 2021, 'Model-Based Drug-Drug Interaction Extrapolation Strategy From Adults to

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Predicting human tissue exposures to xenobiotics using a bottom-up physiologically-based biokinetic model

• Authors : Tan, Pei Feng Shawn

• Source: Tan, P F S 2021, 'Predicting human tissue exposures to xenobiotics using a bottom-up physiologically-based biokinetic model', ALTEX. https://doi.org/10.14573/altex.2007151

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