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Prodrugs Design: a New Era

• Authors : Karaman, Rafik

Subjects: Prodrugs--DesignMEDICAL / Pharmacology

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Proanthocyanidin-Conjugated NIR-ΙΙ Nano-Prodrugs for Reversing Drug Resistance in Photothermal Therapy.

• Authors : Cui, Lan^1,2,3 (AUTHOR); Lou, Weishuang^1,2 (AUTHOR); Wei, Xin^1,3 (AUTHOR)

Subjects: *Multidrug resistance; *Drug resistance; *Drug therapy

• Source: Molecules. Jun2025, Vol. 30 Issue 11, p2334. 19p.

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Synthesis of Enantiostructured Triacylglycerol Prodrugs Constituting an Active Drug Located at Terminal sn -1 and sn -3 Positions of the Glycerol Backbone.

• Authors : Jónsdottir, Lena Rós¹ (AUTHOR); Haraldsson, Gudmundur G.¹ (AUTHOR)

Subjects: *Omega-3 fatty acids; *Asymmetric synthesis; *Benzyl ethers

• Source: Molecules. Mar2025, Vol. 30 Issue 5, p991-1. 23p.

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Application of Lipophilic Prodrug Charge Masking Strategy to Obtain Novel, Potential Oxytocin Prodrugs.

• Authors : Gitlin-Domagalska A; Department of Molecular Biochemistry, Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.; Olejnik A

Subjects: Prodrugs*/Prodrugs*/Prodrugs*/chemistry ; Prodrugs*/Prodrugs*/Prodrugs*/pharmacology ; Prodrugs*/Prodrugs*/Prodrugs*/chemical synthesis

• Source: International journal of molecular sciences [Int J Mol Sci] 2025 May 16; Vol. 26 (10). Date of Electronic Publication: 2025 May 16.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Coenzyme Q 10 as an Inhibitor of Effector Release from One-Electron-Reduced Bioreductive Anticancer Prodrugs.

• Authors : Anderson, Robert F.^1,2,3 (AUTHOR) ; Qi, Wen² (AUTHOR)

Subjects: *Radical anions; *Pulse radiolysis; *Charge exchange

• Source: Molecules. Feb2025, Vol. 30 Issue 4, p760. 12p.

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Novel telomere-targeting dual-pharmacophore dinucleotide prodrugs for anticancer therapy.

• Authors : Mender I; Department of Research and Development, MAIA Biotechnology, Inc., Chicago, IL 60606, United States.; Girotti R

Subjects: Prodrugs*/Prodrugs*/Prodrugs*/pharmacology ; Prodrugs*/Prodrugs*/Prodrugs*/chemistry ; Prodrugs*/Prodrugs*/Prodrugs*/chemical synthesis

• Source: Nucleic acids research [Nucleic Acids Res] 2025 Jun 20; Vol. 53 (12).Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Co-encapsulation of norcantharidin prodrugs and lomitapide in nanoparticles to regulate CCL4 expression by inhibiting Wnt/β-catenin pathway for improved anti-tumor immunotherapy.

• Authors : Zhao F; College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.; Gong L

Subjects: Prodrugs*/Prodrugs*/Prodrugs*/pharmacology ; Prodrugs*/Prodrugs*/Prodrugs*/chemistry ; Bridged Bicyclo Compounds, Heterocyclic*/Bridged Bicyclo Compounds, Heterocyclic*/Bridged Bicyclo Compounds, Heterocyclic*/pharmacology

• Source: Journal of nanobiotechnology [J Nanobiotechnology] 2025 May 21; Vol. 23 (1), pp. 369. Date of Electronic Publication: 2025 May 21.Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155

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Design, Synthesis, and Evaluation of Doxifluridine Derivatives as Nitroreductase-Responsive Anticancer Prodrugs.

• Authors : Zhang, Xinmeng¹ (AUTHOR) ; Dong, Taimin¹ (AUTHOR); Li, Xu¹ (AUTHOR)

Subjects: *Antineoplastic agents; *Tumor microenvironment; *DNA synthesis

• Source: Molecules. Nov2024, Vol. 29 Issue 21, p5077. 11p.

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Oral pharmacokinetics and efficacy of oral phospholipid remdesivir nucleoside prodrugs against SARS-CoV-2 in mice.

• Authors : Carlin, Aaron; Beadle, James; Ardanuy, Jeremy

Subjects: COVID-19; SARS-CoV-2; antiviral agent

• Source: Antimicrobial Agents and Chemotherapy. 68(10)

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Synthesis and Characterization of Novel Co(III)/Ru(II) Heterobimetallic Complexes as Hypoxia-Activated Iron-Sequestering Anticancer Prodrugs.

• Authors : Tran TB; Department of Inorganic & Analytical Chemistry, Faculty of Science & Technology, University of Debrecen, H-4032 Debrecen, Hungary.; Sipos É

Subjects: Coordination Complexes*/Coordination Complexes*/Coordination Complexes*/chemistry ; Coordination Complexes*/Coordination Complexes*/Coordination Complexes*/chemical synthesis ; Coordination Complexes*/Coordination Complexes*/Coordination Complexes*/pharmacology

• Source: Molecules (Basel, Switzerland) [Molecules] 2024 Dec 18; Vol. 29 (24). Date of Electronic Publication: 2024 Dec 18.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

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