Search Results

Poly(ADP-ribose) polymerase-1 and its ambiguous role in cellular life and death

• Authors : Maria Castedo; Antoine Lafarge; Guido Kroemer

Subjects: parp1 inhibition; dna damage; parthanatos

• Source: Cell Stress, Vol 7, Iss 1, Pp 1-6 (2023)

Record details

In Silico Investigation of the Molecular Mechanism of PARP1 Inhibition for the Treatment of BRCA-Deficient Cancers

• Authors : Fengqin Yan; Zhenfu Fu; Guo Li

Subjects: PARP1 inhibition; BRCA deficiency; PARP1 G-quadruplexagris

• Source: Molecules; Volume 28; Issue 4; Pages: 1829

Record details

Discovery of 5‑{4-[(7-Ethyl-6-oxo‑5,6-dihydro‑1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}‑ N ‑methyl­pyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

• Authors : Jeffrey W. Johannes (1414039); Amber Balazs (9436515); Derek Barratt (8921054)

Subjects: Biochemistry; Genetics; Molecular Biology

Record details

Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization Against PARP1 Inhibition in a Replication-Dependent Manner

• Authors : Johanna Rieckhoff; Felix Meyer; Sandra Classen

Subjects: CIN; TNBC; PTEN

• Source: Cancers; Volume 12; Issue 10; Pages: 2809

Record details

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.

• Authors : Wurster, S.; Hennes, F.; Parplys, A.C.

Subjects: Homologous Recombination; Ionizing Radiation; Parp1 Inhibition

• Source: Oncotarget 7, 9732-9741 (2016)

Record details

Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner

• Authors : Sandra Classen; Alexandra Zielinski; Kerstin Borgmann

Subjects: 0301 basic medicine; Cancer Research; PTEN

• Source: CancersVolume 12Issue 10Cancers, Vol 12, Iss 2809, p 2809 (2020)

Record details

PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response

• Authors : Jasna Irena Seelbach; Fabian Hennes; Ann Christin Parplys

Subjects: DNA Replication; 0301 basic medicine; Radiation-Sensitizing Agents

• Source: ResearcherIDOncotargetOncotarget 7, 9732-9741 (2016)

Record details

In Silico Investigation of the Molecular Mechanism of PARP1 Inhibition for the Treatment of BRCA-Deficient Cancers.

• Authors : Yan F; Department of Radiotherapy, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China.; Fu Z

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/drug therapy ; G-Quadruplexes*; Humans

• Source: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 15; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 15.Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049

Record details

Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner.

• Authors : Rieckhoff J; Laboratory of Radiobiology & Experimental Radio Oncology, Centre of Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Meyer F

• Source: Cancers [Cancers (Basel)] 2020 Sep 29; Vol. 12 (10). Date of Electronic Publication: 2020 Sep 29.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print)

Record details

Reduced ADP-ribosylation by PARP1 natural polymorphism V762A and by PARP1 inhibitors enhance Hepatitis B virus replication.

• Authors : Ko HL; Singapore Immunology Network, A*STAR, Singapore.; Ng HJ

Subjects: Poly(ADP-ribose) Polymerase Inhibitors* ; Virus Replication*; Adenosine Diphosphate/Adenosine Diphosphate/Adenosine Diphosphate/*metabolism

• Source: Journal of viral hepatitis [J Viral Hepat] 2013 Sep; Vol. 20 (9), pp. 658-65. Date of Electronic Publication: 2013 Apr 17.Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9435672 Publication Model: Print-Electronic Cited Medium: Internet

Record details