Dual-Functional Silicon-Based Nanofluorescent Platform for Iron Detection and Capecitabine Delivery in Colorectal Cancer Treatment.

Publisher: Springer- Country of Publication: Netherlands NLM ID: 9201341 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4994 (Electronic) Linking ISSN: 10530509 NLM ISO Abbreviation: J Fluoresc Subsets: MEDLINE

Publication: Amsterdam : Springer-
Original Publication: New York : Plenum Press, c1991-

Colorectal Neoplasms*/drug therapy ; Colorectal Neoplasms*/pathology ; Colorectal Neoplasms*/metabolism ; Capecitabine*/chemistry ; Capecitabine*/pharmacology ; Iron*/analysis ; Silicon*/chemistry ; Nanoparticles*/chemistry ; Fluorescent Dyes*/chemistry ; Drug Carriers*/chemistry ; Antineoplastic Agents*/pharmacology ; Antineoplastic Agents*/chemistry ; Drug Delivery Systems*; Cell Survival/drug effects ; Humans

Colorectal cancer (CRC) poses significant challenges due to its high incidence and mortality. Addressing limitations like poor bioavailability and off-target effects of traditional chemotherapy, we engineered PDMS-CP1@1@Capecitabine nanoparticles. This novel formulation incorporates a gadolinium-based coordination polymer synthesized via a hydrothermal reaction with a thiourea Schiff-base ligand and embedded in a polydimethylsiloxane (PDMS) matrix, enhanced by the bioactive compound 1 from actinomycetes. Structural characterization demonstrated a crystalline nature with distinct XRD peaks at 21.4° and 25.6°, alongside remarkable fluorescence with peak emission at 444 nm and superior Fe³⁺ selectivity, showing 90% quenching efficiency against Fe³⁺ compared to other ions. These nanoparticles reduced CRC cell viability by up to 55% at 20 µg/mL, modulating USP22 and HSP90 expression, validated by molecular docking confirming hydrogen bonding interactions. PDMS-CP1@1@Capecitabine emerges as a potent targeted therapy for CRC, enhancing drug delivery and offering a novel approach for iron monitoring, pivotal for personalized treatment strategies.
(© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Declarations. Ethical Approval: Not applicable. Competing Interests: The authors declare no competing interests.

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Keywords: Colorectal cancer; Nanofluorescent; Silicon

6804DJ8Z9U (Capecitabine)
E1UOL152H7 (Iron)
Z4152N8IUI (Silicon)
0 (Fluorescent Dyes)
0 (Drug Carriers)
0 (Antineoplastic Agents)

Date Created: 20250321 Date Completed: 20251203 Latest Revision: 20251203

20260130

10.1007/s10895-025-04252-8

40117054