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Inhalable chitosan nanoparticles as antitubercular drug carriers for an effective treatment of tuberculosis

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Author(s): Tarun, Garg; Goutam, Rath; Amit K, Goyal
Source:
Artificial Cells, Nanomedicine, and Biotechnology. :1-5
Subject Terms:
2. Zero hunger; 0301 basic medicine; Chitosan; Drug Carriers; Mice, Inbred BALB C; 02 engineering and technology; 3. Good health; Disease Models, Animal; Mice; 03 medical and health sciences; Administration, Inhalation; Isoniazid; Animals; Humans; Nanoparticles; Female; Rifampin; 0210 nano-technology; Antibiotics, Antitubercular; Tuberculosis, Pulmonary
Document Type:
Article
Language:
English
Online Access:
https://pubmed.ncbi.nlm.nih.gov/25682840

Additional Information
- Publication Information:
  Informa UK Limited, 2015.
- Publication Date:
  2015
- Abstract:
  The aim of this study was to prepare and characterize spray dried inhalable chitosan nanoparticles (CNPs) for sustained delivery of anti-tubercular drugs, isoniazid (INH) and rifampicin (RIF), to the lungs. CNPs were prepared by ionic gelation technique followed spray drying. Results showed that the CNPs obtained had a smooth spherical shape with an average size of 230 ± 4.5 nm, with a poly dispersity index of 0.180 ± 0.021. Both drugs, were detected in various organs (lungs, liver, spleen and kidney) until 24 h post nebulization. The chemotherapeutic efficacy of a single dose of drug-loaded CNPs suggested that they are more effective against the mycobacterium than free drugs.
- ISSN:
  2169-141X
  2169-1401
- Accession Number:
  10.3109/21691401.2015.1008508
- Accession Number:
  edsair.doi.dedup.....9a2965d027d86678fc47b11d172c84b2

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