Contributors: 1 Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. 2 Department of Clinical Nutrition, Landspitali University Hospital, Reykjavik, Iceland. 3 Faculty of Health, Copenhagen University College, Copenhagen, Denmark. 4 Research Unit for Nutrition, Herlev and Gentofte Hospital, Copenhagen, Denmark. 5 Department of Nutritional Sciences, King's College London, London, UK. 6 The Icelandic Gerontological Research Institute, Landspitali University Hospital and University of Iceland, Reykjavik, Iceland. 7 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 8 Department of Sleep, Landspitali University Hospital, Reykjavik, Iceland.
Abstract: To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download ; INTRODUCTION: Intervention studies have mainly used oral nutritional supplements (ONS) for the management of patients with chronic obstructive pulmonary disease (COPD) identified as at nutritional risk. In this 12-month randomised feasibility trial, we assessed the (1) feasibility of the recruitment, retention and provision of two interventions: ONS and between-meal snacks (snacks) and (2) the potential impact of the provision of snacks and ONS on body weight and quality of life in patients with COPD. METHODS : Hospitalised patients with COPD, at nutritional risk, were randomised to ONS (n=19) or snacks (n=15) providing 600 kcal and 22 g protein a day in addition to regular daily diet. The intervention started in hospital and was continued for 12 months after discharge from the hospital. RESULTS : Study recruitment rate was n=34 (45%) and retention rate at 12 months was similar for both groups: n=13 (68%) in the ONS group and n=10 (67%) in the Snacks group. Both groups gained weight from baseline to 12 months (2.3±4.6 kg (p=0.060) in the ONS group and 4.4±6.4 kg (p=0.030) in the Snacks group). The St George's Respiratory Questionnaire total score improved from baseline to 12 months in both groups (score 3.9±11.0 (p=0.176) in the ONS group and score 8.9±14.1 (p=0.041) in the Snacks group). DISCUSSION : In patients with COPD who are at nutritional risk snacks are at least as feasible and effective as ONS, however, adequately powered trials that take account of the difficulties in recruiting this patient group are required to confirm this effect. ; Icelandic Research Fund of the Icelandic Centre for Research Eimskip University Fund Landspitali University Hospital Research Fund Nutricia (Icepharma)
Processing Request
No Comments.