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A review on the role of ZEB1-AS1 in human disorders

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  • Additional Information
    • Publication Information:
      Elsevier BV
    • Publication Date:
      2023
    • Collection:
      Digital Library Thüringen
    • Abstract:
      ZEB1 Antisense RNA 1 (ZEB1-AS1) is a type of RNA characterized as long non-coding RNA (lncRNA). This lncRNA has important regulatory roles on its related gene, Zinc Finger E-Box Binding Homeobox 1 (ZEB1). In addition, role of ZEB1-AS1 has been approved in diverse malignancies such as colorectal cancer, breast cancer, glioma, hepatocellular carcinoma and gastric cancer. ZEB1-AS1 serves as a sponge for a number of microRNAs, namely miR-577, miR-335-5p, miR-101, miR-505-3p, miR-455-3p, miR-205, miR-23a, miR-365a-3p, miR-302b, miR-299-3p, miR-133a-3p, miR-200a, miR-200c, miR-342-3p, miR-214, miR-149-3p and miR-1224-5p. In addition to malignant conditions, ZEB1-AS1 has functional role in non-malignant conditions like diabetic nephropathy, diabetic lung, arthrosclerosis, Chlamydia trachomatis infection, pulmonary fibrosis and ischemic stroke. This review outlines different molecular mechanisms of ZEB1-AS1 in a variety of disorders and highlights its importance in their pathogenesis.
    • File Description:
      12 Seiten
    • Relation:
      Pathology, research and practice; https://doi.org/10.1016/j.prp.2023.154486
    • Accession Number:
      10.1016/j.prp.2023.154486
    • Online Access:
      https://doi.org/10.1016/j.prp.2023.154486
      https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20240409-145420-001
      https://www.db-thueringen.de/receive/dbt_mods_00059986
      https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00062642/1-s2.0-S0344033823001863-main.pdf
    • Rights:
      https://creativecommons.org/licenses/by/4.0/ ; public ; info:eu-repo/semantics/openAccess
    • Accession Number:
      edsbas.2F81406F