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Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision?

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  • Additional Information
    • Contributors:
      Glycobiologie et signalisation cellulaire; Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM); Laboratory of Biochemistry and Molecular Biology; San Paolo Medical School; Régulations cellulaires: lipidoses et atherosclerose; IFR 31 Louis Bugnard (IFR 31); Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM); Régulations des réactions immunitaires et inflammatoires; Université Nice Sophia Antipolis (1965 - 2019) (UNS)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)
    • Publication Information:
      CCSD
      Taylor & Francis
    • Publication Date:
      2007
    • Collection:
      HAL Université Côte d'Azur
    • Abstract:
      Sphingolipids are major constituents of biological membrane and some of them behave as second messengers involved in the cell fate decision. Ceramide and sphingosine 1-phosphate (S1P) constitute a rheostat system in which ceramide promotes cell death and S1P increases cell survival. We have shown that both sphingolipids are able to trigger autophagy with opposing outcomes on cell survival. Here we discuss and speculate on the diverging functions of the autophagic pathways induced by ceramide and S1P, respectively.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/17035732; PUBMED: 17035732
    • Online Access:
      https://inserm.hal.science/inserm-00172116
      https://inserm.hal.science/inserm-00172116v1/document
      https://inserm.hal.science/inserm-00172116v1/file/05_-_PMID_17035732.pdf
    • Rights:
      https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess
    • Accession Number:
      edsbas.95C5964A