Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Mechanobiology and survival strategies of circulating tumor cells: a process towards the invasive and metastatic phenotype

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Contributors:
      Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Centre de Recherches Ecologiques et Evolutives sur le Cancer (MIVEGEC-CREEC); Processus Écologiques et Évolutifs au sein des Communautés (PEEC); Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD Occitanie )-Université de Montpellier (UM); Centre de Recherche en Ecologie et Evolution de la Santé (CREES); Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM); European Liquid Biopsy Society Hamburg, Germany (ELBS); KK and CA-P are supported by MECA-CTC, which has received funding from INSERM eva3. CA-P is also supported by the National Institute of Cancer (INCa, http://www.e-cancer.fr), SIRIC Montpellier Cancer Grant INCa_Inserm_DGOS_12553, Fondation ARC pour la Recherche sur le cancer, and Fonds de dotation AFER pour la recherche médicale.
    • Publication Information:
      CCSD
      Frontiers media
    • Publication Date:
      2023
    • Collection:
      Université de Montpellier: HAL
    • Abstract:
      International audience ; Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion, intravasation, circulation, arrest/adhesion and extravasation require specific mechanical properties to allow cell survival and the completion of the metastatic cascade. Circulating tumor cells (CTCs) come into contact with the capillary bed during extravasation/intravasation at the beginning of the metastatic cascade. However, CTC mechanobiology and survival strategies in the bloodstream, and specifically in the microcirculation, are not well known. A fraction of CTCs can extravasate and colonize distant areas despite the biomechanical constriction forces that are exerted by the microcirculation and that strongly decrease tumor cell survival. Furthermore, accumulating evidence shows that several CTC adaptations, via molecular factors and interactions with blood components (e.g., immune cells and platelets inside capillaries), may promote metastasis formation. To better understand CTC journey in the microcirculation as part of the metastatic cascade, we reviewed how CTC mechanobiology and interaction with other cell types in the bloodstream help them to survive the harsh conditions in the circulatory system and to metastasize in distant organs.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/37215087; PUBMED: 37215087; PUBMEDCENTRAL: PMC10196185
    • Accession Number:
      10.3389/fcell.2023.1188499
    • Online Access:
      https://hal.science/hal-04945791
      https://hal.science/hal-04945791v1/document
      https://hal.science/hal-04945791v1/file/fcell-11-1188499.pdf
      https://doi.org/10.3389/fcell.2023.1188499
    • Rights:
      https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess
    • Accession Number:
      edsbas.CDE15A9D