Stimulation of bone formation in vitro and in rodents by statins.

Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Print ISSN: 0036-8075 (Print) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-

Transforming Growth Factor beta*; Bone Density/*drug effects ; Lovastatin/*pharmacology ; Osteoblasts/*drug effects ; Osteogenesis/*drug effects ; Simvastatin/*pharmacology; Animals ; Bone Morphogenetic Protein 2 ; Bone Morphogenetic Proteins/biosynthesis ; Bone Morphogenetic Proteins/genetics ; Bone Morphogenetic Proteins/pharmacology ; Cell Line ; Female ; Fibroblast Growth Factor 1 ; Fibroblast Growth Factor 2/pharmacology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Male ; Mice ; Mice, Inbred ICR ; Organ Culture Techniques ; Osteoblasts/metabolism ; Osteoclasts/drug effects ; Osteoporosis/drug therapy ; Ovariectomy ; Promoter Regions, Genetic/drug effects ; Rats ; Recombinant Proteins/pharmacology ; Skull ; Transfection

Osteoporosis and other diseases of bone loss are a major public health problem. Here it is shown that the statins, drugs widely used for lowering serum cholesterol, also enhance new bone formation in vitro and in rodents. This effect was associated with increased expression of the bone morphogenetic protein-2 (BMP-2) gene in bone cells. Lovastatin and simvastatin increased bone formation when injected subcutaneously over the calvaria of mice and increased cancellous bone volume when orally administered to rats. Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis.

Comment in: Science. 1999 Dec 3;286(5446):1825-6. doi: 10.1126/science.286.5446.1825a. (PMID: 10610568)

0 (BMP2 protein, human)
0 (Bmp2 protein, mouse)
0 (Bmp2 protein, rat)
0 (Bone Morphogenetic Protein 2)
0 (Bone Morphogenetic Proteins)
0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
0 (Recombinant Proteins)
0 (Transforming Growth Factor beta)
0 (recombinant human bone morphogenetic protein-2)
103107-01-3 (Fibroblast Growth Factor 2)
104781-85-3 (Fibroblast Growth Factor 1)
9LHU78OQFD (Lovastatin)
AGG2FN16EV (Simvastatin)

Date Created: 19991203 Date Completed: 19991216 Latest Revision: 20220408

20250114

10.1126/science.286.5446.1946

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