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The osteoblast: a sophisticated fibroblast under central surveillance.

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  • Author(s): Ducy P;Ducy P; Schinke T; Karsenty G
  • Source:
    Science (New York, N.Y.) [Science] 2000 Sep 01; Vol. 289 (5484), pp. 1501-4.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Print ISSN: 0036-8075 (Print) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
    • Publication Information:
      Publication: : Washington, DC : American Association for the Advancement of Science
      Original Publication: New York, N.Y. : [s.n.] 1880-
    • Subject Terms:
      Bone Remodeling* ; Osteogenesis*; Osteoblasts/*physiology; Animals ; Cell Differentiation ; Fibroblasts/cytology ; Fibroblasts/physiology ; Growth Substances/physiology ; Homeodomain Proteins/physiology ; Hormones/physiology ; Humans ; Leptin/physiology ; Osteoblasts/cytology ; Osteoclasts/cytology ; Osteoclasts/physiology ; Transcription Factors/physiology
    • Abstract:
      The study of the biology of osteoblasts, or bone-forming cells, illustrates how mammalian genetics has profoundly modified our understanding of cell differentiation and physiologic processes. Indeed, genetic-based studies over the past 5 years have revealed how osteoblast differentiation is controlled through growth and transcription factors. Likewise, the recent identification, using mutant mouse models, of a central component in the regulation of bone formation expands our understanding of the control of bone remodeling. This regulatory loop, which involves the hormone leptin, may help to explain the protective effect of obesity on bone mass in humans. In addition, it provides a novel physiologic concept that may shed light on the etiology of osteoporosis and help to identify new therapeutic targets.
    • Number of References:
      48
    • Accession Number:
      0 (Growth Substances)
      0 (Homeodomain Proteins)
      0 (Hormones)
      0 (Leptin)
      0 (Transcription Factors)
    • Publication Date:
      Date Created: 20000901 Date Completed: 20000914 Latest Revision: 20220316
    • Publication Date:
      20250114
    • Accession Number:
      10.1126/science.289.5484.1501
    • Accession Number:
      10968779