Outbreak of aseptic meningitis and mumps after mass vaccination with MMR vaccine using the Leningrad–Zagreb mumps strain

Data from routine surveillance during two mass immunisation campaigns (MIC) with Measles–mumps–rubella (MMR)vaccine using Leningrad–Zagreb mumps strain in two states in Brazil were analysed to estimate the risk of vaccine-related meningitis and mumps. Increase in the incidence of the two diseases was observed in both states, 3 weeks after the vaccination campaigns. The estimated number of doses applied per one case of vaccine-related meningitis ranged from 6199 (95% CI: 4854–8058) to 19,247 (95% CI: 12,648–29,513) depending on the diagnostic criteria used and state. It was 300 doses (95% CI: 286–317) for each case of mumps. The implications for vaccination policy are discussed. [Copyright &y& Elsevier]