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Temperature and concentration calibration of aqueous polyvinylpyrrolidone (PVP) solutions for isotropic diffusion MRI phantoms.
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- Author(s): Wagner, Friedrich1; Laun, Frederik B.1,2; Kuder, Tristan A.1; Mlynarska, Anna3; Maier, Florian1; Faust, Jonas1; Demberg, Kerstin1; Lindemann, Linus1; Rivkin, Boris1; Nagel, Armin M.1,2; Ladd, Mark E.1; Maier-Hein, Klaus4; Bickelhaupt, Sebastian3; Bach, Michael1
- Source:
PLoS ONE. 6/19/2017, Vol. 12 Issue 6, p1-13. 13p.
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- Abstract:
To use the “apparent diffusion coefficient” (Dapp) as a quantitative imaging parameter, well-suited test fluids are essential. In this study, the previously proposed aqueous solutions of polyvinylpyrrolidone (PVP) were examined and temperature calibrations were obtained. For example, at a temperature of 20°C, Dapp ranged from 1.594 (95% CI: 1.593, 1.595) μm2/ms to 0.3326 (95% CI: 0. 3304, 0.3348) μm2/ms for PVP-concentrations ranging from 10% (w/w) to 50% (w/w) using K30 polymer lengths. The temperature dependence of Dapp was found to be so strong that a negligence seems not advisable. The temperature dependence is descriptively modelled by an exponential function exp(c2 (T − 20°C)) and the determined c2 values are reported, which can be used for temperature calibration. For example, we find the value 0.02952 K-1 for 30% (w/w) PVP-concentration and K30 polymer length. In general, aqueous PVP solutions were found to be suitable to produce easily applicable and reliable Dapp-phantoms. [ABSTRACT FROM AUTHOR]
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