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Silent latency periods in methylmercury poisoning and in neurodegenerative disease.

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  • Author(s): Weiss B;Weiss B; Clarkson TW; Simon W
  • Source:
    Environmental health perspectives [Environ Health Perspect] 2002 Oct; Vol. 110 Suppl 5, pp. 851-4.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Print ISSN: 0091-6765 (Print) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
    • Subject Terms:
      Food Contamination*; Mercury Poisoning/*physiopathology ; Methylmercury Compounds/*poisoning ; Neurodegenerative Diseases/*chemically induced; Acute Disease ; Chronic Disease ; Humans ; Iraq ; Kinetics ; Methylmercury Compounds/pharmacokinetics ; Time Factors
    • Abstract:
      This article discusses three examples of delay (latency) in the appearance of signs and symptoms of poisoning after exposure to methylmercury. First, a case is presented of a 150-day delay period before the clinical manifestations of brain damage after a single brief (<1 day) exposure to dimethylmercury. The second example is taken from the Iraq outbreak of methylmercury poisoning in which the victims consumed contaminated bread for several weeks without any ill effects. Indeed, signs of poisoning did not appear until weeks or months after exposure stopped. The last example is drawn from observations on nonhuman primates and from the sequelae of the Minamata, Japan, outbreak in which low chronic doses of methylmercury may not have produced observable behavioral effects for periods of time measured in years. The mechanisms of these latency periods are discussed for both acute and chronic exposures. Parallels are drawn with other diseases that affect the central nervous system, such as Parkinson disease and post-polio syndrome, that also reflect the delayed appearance of central nervous system damage.
    • Number of References:
      24
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    • Grant Information:
      P30 ES 01247 United States ES NIEHS NIH HHS; R01 ES 08442 United States ES NIEHS NIH HHS; R01 ES 08958 United States ES NIEHS NIH HHS; R01 ES 10219 United States ES NIEHS NIH HHS
    • Accession Number:
      0 (Methylmercury Compounds)
    • Publication Date:
      Date Created: 20021112 Date Completed: 20021224 Latest Revision: 20181113
    • Publication Date:
      20250114
    • Accession Number:
      PMC1241259
    • Accession Number:
      10.1289/ehp.02110s5851
    • Accession Number:
      12426145