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Targeted Cationic Liposomes: Technologies and Developments.

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  • Author(s): EI-Aneed, Anas
  • Source:
    Pharmaceutical Technology Europe. Feb2004, Vol. 16 Issue 2, p35-40. 4p. 2 Color Photographs.
  • Additional Information
    • Subject Terms:
      Cations; Liposomes; Gene therapy; Tissue-specific antibodies; Gene transfection; Receptor-ligand complexes; Therapeutics
    • Abstract:
      Cationic liposomes are widely used in gene therapy as a safe alternative to highly immunogenic viral vectors. Attachment of a tissue-specific ligand to the surface of the liposomes can increase specificity and reduce undesired transfection. Targeted liposomes can be categorized as either immunoliposomes or ligand-targeted liposomes. The author provides a brief review of tumour-specific and liver-targeted cationic liposomes and strategies for the development of liposome-ligand complexes. [ABSTRACT FROM AUTHOR]
    • Abstract:
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