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A marine microbiome antifungal targets urgent-threat drug-resistant fungi.
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- Author(s): Zhang, Fan; Zhao, Miao; Braun, Doug R.; Ericksen, Spencer S.; Piotrowski, Jeff S.; Nelson, Justin; Peng, Jian; Ananiev, Gene E.; Chanana, Shaurya; Barns, Kenneth; Fossen, Jen; Sanchez, Hiram; Chevrette, Marc G.; Guzei, Ilia A.; Zhao, Changgui; Guo, Le; Tang, Weiping; Currie, Cameron R.; Rajski, Scott R.; Audhya, Anjon
- Source:
Science. 11/20/2020, Vol. 370 Issue 6519, p974-978. 5p. 2 Color Photographs, 1 Graph.
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- Abstract:
New antifungal drugs are urgently needed to address the emergence and transcontinental spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging the microbiomes of marine animals and cutting-edge metabolomics and genomic tools, we identified encouraging lead antifungal molecules with in vivo efficacy. The most promising lead, turbinmicin, displays potent in vitro and mouse-model efficacy toward multiple-drug–resistant fungal pathogens, exhibits a wide safety index, and functions through a fungal-specific mode of action, targeting Sec14 of the vesicular trafficking pathway. The efficacy, safety, and mode of action distinct from other antifungal drugs make turbinmicin a highly promising antifungal drug lead to help address devastating global fungal pathogens such as C. auris. [ABSTRACT FROM AUTHOR]
- Abstract:
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