抗中性粒细胞细胞质抗体相关性血管炎患者 血清IgG4 表达水平及临床意义.

Expression level and clinical significance of serum IgG4 in patients with antineutrophilic cytoplasmic antibody-associated vasculitis'.

Objective To study the expression level and clinical significance of serum IgG4 in the patients with antineutro philic cytoplasmic antibody associated vasculitis(AAV) . Methods The serum samples in 85 patients with AAV definitely diag nosed in the Second Affiliated Hospital of Chongqing Medical University from April 2018 to April 2020 were collected, including 65 cases of anti myeloperoxidase antibody positive AAV ( MPO AAV subtype) and 20 cases of anti proteinase 3 antibody positive AAV (PR3 AAV subtype), and contemporaneous 35 serum samples from the subjects undergoing the healthy physical examination in the hospital were collected as the control group. T he levels of serum IgG4, IgG, anti MPO antibodies and anti PR3 antibodies were tested. Then the levels of IgG4 and IgG4/IgG ratio were compared among the AAV group,control group, subjects with MPO AAV subtype and subjects with PR3 AAV subtype. Moreover the correlation between the IgG4 level with the anti MPO antibody and anti PR3 antibody levels was analyzed. Results The IgG4 level and IgG4/IgG ratio in the AAV group were significantly higher than those in the control group, and the differences were statistically significant (P O. 05). T he IgG4 level in the patients with MPO AAV subtype had weakly positive correlation with the anti MPO antibody level (r = 0. 443,P = 0. 001),and the IgG4 level in the patients with PR3 AAV subtype had no the correlation with the anti PR3 antibody level (r = 0. 300,P = 0. 198). Conclusion The serum IgG4 level in the patient with AAV is higher. The de tection of IgG4 could assist the clinical diagnosis of AAV. [ABSTRACT FROM AUTHOR]

的 祥完就中性粒細胞细胞质就体相关性血管天(AAV)态者血清免疫球蛋白 G1(IgG4)的表达水手及松库意 又,方法教集 2018年4月至 2020年4月重庆医科大学附属第二医 诊的85例AAV惠者血清(AAV组).其中批義过氧化 物酶(MPO)体阳性 AAV(MPO-AAV 圣型》患者65例.玩蛋白勝3(PR3)抗体阳性AAV(PR3-AAV亚型)患者20 例;教集同 期到重庆医科大学附属第二医院体检的 35 名健康体校者血清(对照组),进行IgA、IgG、玩MPO花体、玩PR3 玩体校测,比较 AAV 组、对照姐、MPO-AAV亚型」PR3-AAV亚型研究对象 IgG4 水平和IgG4/IgG 比值,并分析IgG4水平与款 MPO 抗体水 平、起 PR3 抗体水平的相关性,结果AAV组志者 IgG4水平,JgG4/IgG比值均明显高于时照组,后异均有统计学意又(P< 0.05);MPO-AAV亚型志者 IgG4水平、lgG4/IgG 比值与 PR3-AAV 更型比较,差异均无计学意义(P >0.05). MPO-AAV亚 型急者IgG4水平与抗 MPO批休水平 明是正向相关(r 0.143, P-0.001);PR3-AAV亚型惠者lgG1水平与拉 PR3 就体术 平无关(r=0.300, P-0.198).结论 AAV患者血清 IgGA表达水平校高,检测IgG4可輔助临床诊斯AAV. [ABSTRACT FROM AUTHOR]