Characterization of a common susceptibility locus for asthma-related traits.

Item request has been placed!

Item request cannot be made.

Processing Request

Read Online Read More Add to Saved list

Author(s): Laitinen T;Laitinen T; Polvi A; Rydman P; Vendelin J; Pulkkinen V; Salmikangas P; Mäkelä S; Rehn M; Pirskanen A; Rautanen A; Zucchelli M; Gullstén H; Leino M; Alenius H; Petäys T; Haahtela T; Laitinen A; Laprise C; Hudson TJ; Laitinen LA; Kere J
Source:
Science (New York, N.Y.) [Science] 2004 Apr 09; Vol. 304 (5668), pp. 300-4.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
Language:
English

Additional Information
- Source:
  Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
- Publication Information:
  Publication: : Washington, DC : American Association for the Advancement of Science
  Original Publication: New York, N.Y. : [s.n.] 1880-
- Subject Terms:
  Genetic Predisposition to Disease* ; Haplotypes*; Asthma/*genetics ; Chromosomes, Human, Pair 7/*genetics ; Receptors, G-Protein-Coupled/*genetics; Algorithms ; Alternative Splicing ; Animals ; Asthma/metabolism ; Bronchi/chemistry ; Bronchi/cytology ; Epithelial Cells/chemistry ; Female ; Finland ; Gene Expression ; Genes ; Genetic Linkage ; Genetic Variation ; Genotype ; Humans ; Hypersensitivity/genetics ; Hypersensitivity/metabolism ; Immunoglobulin E/blood ; Inflammation/genetics ; Lung/metabolism ; Male ; Mice ; Myocytes, Smooth Muscle/chemistry ; Polymorphism, Single Nucleotide ; Quebec ; Receptors, G-Protein-Coupled/analysis
- Abstract:
  Susceptibility to asthma depends on variation at an unknown number of genetic loci. To identify susceptibility genes on chromosome 7p, we adopted a hierarchical genotyping design, leading to the identification of a 133-kilobase risk-conferring segment containing two genes. One of these coded for an orphan G protein-coupled receptor named GPRA (G protein-coupled receptor for asthma susceptibility), which showed distinct distribution of protein isoforms between bronchial biopsies from healthy and asthmatic individuals. In three cohorts from Finland and Canada, single nucleotide polymorphism-tagged haplotypes associated with high serum immunoglobulin E or asthma. The murine ortholog of GPRA was up-regulated in a mouse model of ovalbumin-induced inflammation. Together, these data implicate GPRA in the pathogenesis of atopy and asthma.
- Comments:
  Comment in: Science. 2004 Apr 9;304(5668):185-7. doi: 10.1126/science.304.5668.185. (PMID: 15073340)
- Accession Number:
  0 (NPSR1 protein, human)
  0 (Receptors, G-Protein-Coupled)
  37341-29-0 (Immunoglobulin E)
- Publication Date:
  Date Created: 20040410 Date Completed: 20040503 Latest Revision: 20101118
- Publication Date:
  20250114
- Accession Number:
  10.1126/science.1090010
- Accession Number:
  15073379

Comments

No Comments.

Characterization of a common susceptibility locus for asthma-related traits.

Contact

Follow us