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Ideal discrimination of discrete clinical endpoints using multilocus genotypes.

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  • Author(s): Hahn LW;Hahn LW; Moore JH
  • Source:
    In silico biology [In Silico Biol] 2004; Vol. 4 (2), pp. 183-94.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: Netherlands NLM ID: 9815902 Publication Model: Print Cited Medium: Print ISSN: 1386-6338 (Print) Linking ISSN: 13866338 NLM ISO Abbreviation: In Silico Biol Subsets: MEDLINE
    • Publication Information:
      Publication: 2025- : [Thousand Oaks, CA] : SAGE Publications
      Original Publication: Amsterdam ; Washington, DC : [Tokyo] : IOS Press ; Ohmsha, c1998-
    • Subject Terms:
      Genetics* ; Genotype* ; Models, Genetic*; Computational Biology/*methods; Animals ; Bayes Theorem ; Epistasis, Genetic ; Genetic Predisposition to Disease ; Humans ; Psychophysics ; Retina/physiology ; Vision, Ocular ; Visual Perception
    • Abstract:
      Multifactor Dimensionality Reduction (MDR) is a method for the classification and prediction of discrete clinical endpoints using attributes constructed from multilocus genotype data. Empirical studies with both real and simulated data suggest that MDR has good power for detecting gene-gene interactions in the absence of independent main effects. The purpose of this study is to develop an objective, theory-driven approach to evaluate the strengths and limitations of MDR. To accomplish this goal, we borrow concepts from ideal observer analysis used in visual perception to evaluate the theoretical limits of classifying and predicting discrete clinical endpoints using multilocus genotype data. We conclude that MDR ideally discriminates between low risk and high risk subjects using attributes constructed from multilocus genotype data. We also how that the classification approach used once a multilocus attribute is constructed is similar to that of a naive Bayes classifier. This study provides a theoretical foundation for the continued development, evaluation, and application of the MDR as a data mining tool in the domain of statistical genetics and genetic epidemiology.
    • Grant Information:
      AG19085 United States AG NIA NIH HHS; AG20135 United States AG NIA NIH HHS; GM31304 United States GM NIGMS NIH HHS; HL65234 United States HL NHLBI NIH HHS; HL65962 United States HL NHLBI NIH HHS
    • Publication Date:
      Date Created: 20040427 Date Completed: 20050505 Latest Revision: 20081121
    • Publication Date:
      20250114
    • Accession Number:
      15107022