Editorial of Special Issue: The Toxicity of Nanomaterials and Legacy Contaminants: Risks to the Environment and Human Health.

Nanotechnology and the incorporation of nanomaterials (NM) into everyday products help to solve problems in society and improve the quality of life, allowing for major advances in the technological, industrial, and medical fields. 33921715 6 Bessa M.J., Brandão F., Rosário F., Moreira L., Reis A.T., Valdiglesias V., Laffon B., Fraga S., Teixeira J.P. Assessing the in Vitro Toxicity of Airborne (Nano)Particles to the Human Respiratory System: From Basic to Advanced Models. These models also offer the benefits of reduced costs and ethical concerns over animal welfare (3Rs principle), usually resulting in the faster toxicity screening of chemicals, an advantage considering the increasing number of materials and contaminant combinations to be tested. Even though the respiratory system is one the main direct targets (the gastro-intestinal system is also considered one in the case of ingestion), NM can reach the circulatory system, cross blood-organ barriers, and cause toxicity to other organs [[14]]. [Extracted from the article]

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