Biomarker for cardiorenal syndrome risk in patients with liver cirrhosis and type 2 diabetes in Saudi Arabia.

تتناول المقالة المؤشرات الحيوية المرتبطة بخطر تطوير متلازمة القلب والكلى (CRS) لدى المرضى الذين يعانون من تليف الكبد (LC) ومرض السكري من النوع الثاني (T2DM) في المملكة العربية السعودية. أظهرت تحليل رجعي لـ 500 مريض تم إدخالهم إلى المستشفى أن التحكم السيئ في مستوى السكر في الدم، وارتفاع ضغط الدم، والسمنة، وارتفاع مستويات المؤشرات الحيوية كانت شائعة، حيث كان 22.6% منهم في خطر مرتفع للإصابة بأمراض الكلى المزمنة (CKD)، و20% لأمراض القلب والأوعية الدموية (CVD)، و18.2% لمتلازمة القلب والكلى (CRS). تؤكد الدراسة على الحاجة إلى التعرف المبكر على عوامل الخطر وإجراء المزيد من الأبحاث حول المؤشرات الحيوية الجديدة لتعزيز تشخيص وإدارة هذه القضايا الصحية المترابطة. كما تناقش التفاعلات الفسيولوجية المرضية بين خلل وظائف القلب والكلى، خاصة في سياق فشل القلب ومرض السكري. [Extracted from the article]

Objectives: To evaluate the correlation between different attributes, levels of biomarkers, and the probability of developing cardiorenal syndrome (CRS) in patients who have been diagnosed with type 2 diabetes mellitus (T2DM) and liver cirrhosis (LC). The hypothesis suggests that liver illness may be linked to renal impairment, cardiac dysfunction, and the development of cardiorenal syndrome Methods: The current study retrospectively assessed the medical records of patients who had LC and T2DM diagnoses and were hospitalized at Al Madina Al Munwara hospitals in 2022 and 2023. Original Article Results: This research investigated T2DM patients with physician-confirmed to have LC. Poor glycemic control is indicated by high blood glucose and glycated hemoglobin (HbA1c) readings in research participants. High blood pressure, atherogenic plasma indicator (AIP), and obesity plagued most of these individuals. High creatinine, moderate estimated Glomerular Filtration Rate (eGFR) decline, and a modest urinary albumin-to-creatinine (UACR) rise were the most prevalent variables in LC and T2DM patients. Cardiorenal syndrome risk factors, including elevated blood pressure, triglyceride levels, body mass index (BMI), and high-sensitivity C-reactive protein (hs-CRP) concentrations, were identified through logistic regression. It has been demonstrated that the prevalence of these risk factors increases with age; women may be at a greater risk for developing CRS. Specific biomarker evaluations classified 108 (22.6%) LC and T2DM patients at high risk for chronic kidney disease (CKD), 100 (20%) at risk for cardiovascular disease (CVD), and 91 (18.2%) at risk for CRS. Conclusion: The current assessment included 500 patients with T2DM and LC. The risk factors for CRS identified in this study included elevated cholesterol and triglyceride levels, high BMI, and elevated blood pressure, with age being a significant factor, particularly in female patients. Early identification of these characteristics in patients with LC and T2DM could aid in mitigating the progression of chronic illnesses and their associated complications. [ABSTRACT FROM AUTHOR]

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