Serum Uric Acid/Albumin Ratio and Short-Term Outcomes in ST Elevation Myocardial Infarction.

تتناول المقالة العلاقة بين نسبة حمض اليوريك إلى الألبومين (UAR) والنتائج قصيرة المدى لدى المرضى الذين يعانون من احتشاء عضلة القلب مع ارتفاع ST (STEMI) والذين خضعوا لتدخلات القلب التاجية عن طريق الجلد (PCI). أظهرت دراسة قائمة على مجموعة من 80 مريضًا أن أولئك الذين تعرضوا لحدوث أحداث قلبية وعائية سلبية كبيرة (MACE) كانت لديهم مستويات أعلى من حمض اليوريك وUAR، حيث أظهر UAR القدرة على التنبؤ بـ MACE بدقة تصل إلى 81% وحساسية 76% عند نقطة قطع 1.6. كما وجدت الدراسة ارتباطات بين UAR وتصنيف كيلب (Killip) وMACE، في حين كانت نسبة قذف البطين الأيسر (LVEF) مرتبطة عكسيًا بـ MACE. تسلط النتائج الضوء على إمكانيات هذه المؤشرات الحيوية في تحسين إدارة المرضى والتنبؤ بالنتائج القلبية الوعائية. [Extracted from the article]

Background: Serum Albumin (SA) and uric acid (UA) production and excretion could be correlated with major adverse cardiovascular events (MACE) among cases who had ST Elevation Myocardial Infarction (STEMI) and undergone primary Percutaneous Coronary Intervention (PCI). We aimed to assess the relation between high Uric Acid Albumin Ration (UAR) and short-term outcomes among patients who had STEMI and undergone primary PCI. Methods: we carried out this cohort study on 80 patients who had STEMI (and confirmed by cardiac enzymes and ECG) divided into two groups: Group I: patients with MACE. (n=33) and Group II: patients without MACE. (n=47), as determined by the modified Dukes criteria. Both groups undergone primary percutaneous intervention. Serum Uric acid, Serum Albumin, and cardiac enzymes (CK, CK-MB, Troponin) were assessed on admission with follow up of cardiac enzymes post procedure. Results: MACE group had significantly higher uric acid and UAR levels than the non-MACE group (P value <0.01). UAR could significantly predict development of MACE (AUC = 0.65) at cut-off: 1.6 with 81% sensitivity, 76 % specificity. A statistically significant correlation was revealed between the 2 groups in Killip classification (p<0.001), UA, UAR, RWMSI & LVEF (p=0.012, 0.016, 0.002 and 0.014 respectively). Positive correlations were found between Killip Classification, UA, UAR, RWMSI and MACE were revealed (p=0.012, 0.016, and 0.014 respectively) while an inverse relationship between LVEF and MACE was found (p=0.002). Conclusions: Uric acid-to-albumin ratio could significantly predict development of MACE among patients who had STEMI undergoing PCI with high sensitivity and specificity. UA, UAR, RWMSI and Killip classification were positively correlated with MACE while LVEF was inversely related with MACE. [ABSTRACT FROM AUTHOR]

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