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Diagnostic efficiency of DCE-MRI combined with DWI for breast cancer and the relationship between imaging characteristics and molecular biological markers.

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    • Abstract:
      تتناول المقالة كفاءة التشخيص لتصوير الرنين المغناطيسي المحسن بالتباين الديناميكي (DCE-MRI) المدمج مع التصوير بالوزن الانتشاري (DWI) لسرطان الثدي، بالإضافة إلى العلاقة بين خصائص التصوير والعلامات البيولوجية الجزيئية. شملت الدراسة 120 مريضة تعاني من آفات مشتبه بها في الثدي، وكشفت عن قيمة توافق كابا عالية تبلغ 0.817 بين تشخيصات الرنين المغناطيسي والتشخيصات المرضية، مع معدلات حساسية وخصوصية ودقة بلغت 96.05% و84.09% و91.67% على التوالي. تشير النتائج إلى أن بعض ميزات التصوير، مثل قطر الورم وشكله، ترتبط بشكل كبير مع العلامات الجزيئية مثل مستقبلات الاستروجين (ER) ومُستقبلات البروجستيرون (PR) وHER-2 وKi-67، مما يوحي بأن تقنيات التصوير المدمجة يمكن أن تعزز الكشف المبكر وتساعد في توجيه استراتيجيات العلاج الشخصية لسرطان الثدي. [Extracted from the article]
    • Abstract:
      Background: To analyze the diagnostic efficiency of DCE-MRI combined with DWI for breast cancer and the relationship between imaging characteristics and molecular biological markers. Materials and Methods: A total of 120 patients with suspected breast lesions in the hospital were enrolled between January 2021 and October 2023, all underwent MRI examination to obtain DCE-MRI and DWI data. Taking results of pathological diagnosis as the golden standard, diagnostic efficiency of DCE-MRI combined with DWI for breast cancer was analyzed by Kappa consistency test. The expressions of ER, PR, HER-2 and Ki-67 in cancer tissues was detected by immunohistochemistry. The relationship between DCE-MRI, DWI characteristics and molecular biological markers was analyzed. Results: The consistency Kappa value between MRI and pathology 0.817, and its sensitivity, specificity and accuracy were 96.05%, 84.09% and 91.67%, respectively. In patients with breast cancer, tumor diameter was significantly correlated with the expressions of ER, HER-2 and Ki-67 in cancer tissues, tumor morphology was significantly correlated with the expressions of ER, PR, HER-2 and Ki-67, tumor margin was significantly correlated with the expressions of ER and PR, TIC type was significantly correlated with Ki-67 expression, EPER was significantly correlated with HER-2 expression, TTP was significantly correlated with Ki-67 expression, ADC value was significantly correlated with Ki-67 expression, and the above differences were statistically significant (P<0.05). Conclusion: DCE-MRI combined with DWI has high diagnostic efficiency for breast cancer, and their imaging characteristics are related to molecular biological markers to some extent. Imaging examination can further reflect biological behaviors of breast cancer indirectly. [ABSTRACT FROM AUTHOR]
    • Abstract:
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