运动改善多发性硬化症患者生理功能的潜在生物学机制. (Chinese)

Potential biological mechanisms of exercise-induced improvements in physiological function of patients with multiple sclerosis. (English)

BACKGROUND: Exercise has been shown to offer potential benefits for patients with multiple sclerosis, but the specific mechanisms remain unclear. OBJECTIVE: To summarize the physiological changes in patients with multiple sclerosis and to explore the specific mechanisms by which exercise improves these physiological functions. METHODS: A comprehensive literature search was conducted in the Web of Science, PubMed, CNKI, WanFang, and VIP from database inception to June 2024. The search terms were "multiple sclerosis, demyelinating autoimmune diseases, exercise, physical activity, neurodegenerative diseases" in English and Chinese. Based on the predefined inclusion and exclusion criteria, 81 articles were ultimately selected for review. RESULTS AND CONCLUSION: The complex physiological and functional alterations in patients with multiple sclerosis seriously affect their quality of life and ability to live independently. As a non-pharmacological intervention, exercise shows significant potential in improving the physiological and functional status of patients with multiple sclerosis by alleviating fatigue, modulating immune responses, reducing stress hormone levels, enhancing blood-brain barrier function, and promoting neuroplasticity. However, current research on the specific mechanisms of exercise in the treatment of multiple sclerosis is still insufficient, and more high-quality, systematic studies are needed to further validate and refine the findings. Future research should focus on: 1) to develop the most suitable exercise regimens by further exploring the effects of different types and intensities of exercise on the physiological function and disease progression in patients with multiple sclerosis; 2) to verify the long-term effects and safety of exercise in patients with multiple sclerosis through large-scale, long-term follow-up clinical trials; 3) to reveal the specific mechanisms of exercise intervention in patients with multiple sclerosis using advanced technological methods such as functional magnetic resonance imaging and neuroelectrophysiology; and 4) to develop personalized exercise programs based on individual patient differences to optimize intervention effects and patient compliance. [ABSTRACT FROM AUTHOR]

背景: 研究证实运动对多发性硬化症具有潜在的改善作用, 但具体机制尚不完全清楚。 目的: 总结多发性硬化症患者的生理功能变化, 探讨运动改善多发性硬化症患者生理功能的机制。 方法: 应用计算机检索Web of Science, PubMed, 中国知网, 万方和维普数据库等, 中文检索词为 "多发性硬化症, 脱髓鞘自身免疫疾 病, 运动, 体育锻炼, 神经退行性疾病" 等, 英文检索词为 "Multiple sclerosis, Demyelinating Autoimmune Diseases, Exercise, Physical activity, Neurodegenerative diseases" 等, 文献检索时限为各数据库建库至2024年6月, 根据预定的纳入和排除标准, 最终筛选出81篇文献 进行综述。 结果与结论: 多发性硬化症患者的生理和功能变化复杂多样, 严重影响患者的生活质量和独立生活能力。运动作为-种非药物干预方式, 在改善多发性硬化症患者的生理和功能状态方面显示出显著潜力, 运动可以缓解疲劳, 调节免疫反应, 降低压力激素水平, 增强血脑屏障 功能及促进神经可塑性。然而, 当前关于运动治疗多发性硬化症的具体机制研究仍然不足, 需要更多高质量, 系统性的研究来进-步验证 和完善相关结论。未来的研究应聚焦于以下几个方面: 进-步探索不同类型和强度运动对多发性硬化症患者生理功能和病情进展的具体影 响, 找出最适合多发性硬化症患者的运动方案; 开展大规模, 长期随访的临床试验, 验证运动对多发性硬化症患者的长期效果和安全性; 结合现代科技手段, 如功能性磁共振成像和神经电生理技术, 深入揭示运动干预对多发性硬化症患者神经系统的具体作用机制; 考虑患者 个体差异, 制定个性化的运动干预方案, 以最大程度地提高干预效果和患者依从性. [ABSTRACT FROM AUTHOR]

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