In Vitro Assessment of Bacillus thuringiensis Exopolysaccharides and Their Effects on Gut Microbiota from Ulcerative Colitis In Vitro.

Item request has been placed!

Item request cannot be made.

Processing Request

Read Online Read More Add to Saved list

Author(s): Gao, Zexin^1,2 (AUTHOR); Tang, Jie^1,2 (AUTHOR); Wu, Chuanchao^2,3 (AUTHOR); Ding, Wenping¹ (AUTHOR); Wang, Xianyi^1,2 (AUTHOR); Long, Yaohang^1,3 (AUTHOR); Wang, Yaping¹ (AUTHOR); Liu, Hongmei^1,3 (AUTHOR)
Source:
International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1692. 19p.
Subject Terms:
*ULCERATIVE colitis; *SHORT-chain fatty acids; *FOOD additives; *OXIDANT status; *GUT microbiome; *BACILLUS thuringiensis

Additional Information
- Abstract:
  Bacillus thuringiensis exopolysaccharide BPS-2 inhibits malondialdehyde secretion, enhances antioxidant enzyme activities, and significantly improves the antioxidant status of inflammatory cells. In the present study, the apparent morphology and spatial conformation of BPS-2 were analyzed further, and several functional properties were investigated. The results demonstrated that BPS-2 was a polymeric straight-chain polysaccharide with good thermal stability, exhibiting non-Newtonian properties and good antioxidant and anticancer activities. Notably, this study systematically investigated the impact of BPS-2 on the intestinal microbiota composition in patients diagnosed with ulcerative colitis. Through in vitro fermentation of fecal bacteria collected from six volunteers, it was found that BPS-2 exerted a positive influence on the intestinal flora of ulcerative colitis patients, augmenting the secretion of short-chain fatty acids and facilitating an increase in the relative abundance of Bifidobacterium spp. These results suggest that BPS-2 has the potential to be a food additive for suppressing ulcerative colitis and for other medically related applications. [ABSTRACT FROM AUTHOR]