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Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
    • Publication Information:
      Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK
      Original Publication: London, Lewis.
    • Subject Terms:
      Adiponectin/*pharmacology ; Breast Neoplasms/*metabolism ; Epithelial Cells/*drug effects ; Gene Expression/*drug effects ; Gene Expression Regulation/*physiology ; Mammary Glands, Human/*drug effects; Adiponectin/metabolism ; Cell Line ; Cell Proliferation/drug effects ; Epithelial Cells/metabolism ; Female ; Gene Expression/physiology ; Humans ; Mammary Glands, Human/cytology ; Mammary Glands, Human/metabolism ; Oligonucleotide Array Sequence Analysis ; Reverse Transcriptase Polymerase Chain Reaction
    • Abstract:
      Serum levels of adiponectin are inversely associated with breast cancer risk. In this study, its effect on growth and gene expression of MCF-7 breast cancer cells and MCF-10A human mammary epithelial cells was compared. The antiproliferative effect of adiponectin on MCF-10A cells was more pronounced and was accompanied by elevated transcript levels of caspase 1, ERbeta2, ERbeta5, TR2 and USP2. Our data suggest that upregulation of genes with known growth inhibitory or apoptotic functions in mammary epithelial cells might contribute to the protective action of this adipocytokine.
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    • Accession Number:
      0 (Adiponectin)
    • Publication Date:
      Date Created: 20081002 Date Completed: 20081104 Latest Revision: 20181113
    • Publication Date:
      20250114
    • Accession Number:
      PMC2570517
    • Accession Number:
      10.1038/sj.bjc.6604692
    • Accession Number:
      18827813