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Effect of anaemia on mortality, cardiovascular hospitalizations and end-stage renal disease among patients with chronic kidney disease.

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  • Additional Information
    • Source:
      Publisher: Blackwell Science Country of Publication: Australia NLM ID: 9615568 Publication Model: Print Cited Medium: Internet ISSN: 1440-1797 (Electronic) Linking ISSN: 13205358 NLM ISO Abbreviation: Nephrology (Carlton) Subsets: MEDLINE
    • Publication Information:
      Original Publication: Carlton, Vic., Australia : Blackwell Science,
    • Subject Terms:
      Anemia/*mortality ; Cardiovascular Diseases/*mortality ; Kidney Diseases/*mortality ; Kidney Failure, Chronic/*mortality; Adult ; Aged ; Anemia/complications ; Chronic Disease ; Cohort Studies ; Female ; Glomerular Filtration Rate ; Hemoglobins/analysis ; Hospitalization ; Humans ; Male ; Middle Aged ; Retrospective Studies
    • Abstract:
      Objective: To determine whether an independent association exists between anaemia and chronic kidney disease (CKD) outcomes in a quasi-incidence cohort when patients' most recent laboratory values are considered.
      Methods: We conducted a dynamic, retrospective cohort study among patients with incident CKD in a large health maintenance organization administrative data set. CKD was defined by two estimated glomerular filtration rates (eGFR). We measured the absolute rates for all-cause mortality, cardiovascular hospitalizations and end-stage renal disease.
      Results: Our completed cases Cox regression model followed 5885 patients with both CKD and haemoglobin measures. For patients with the most severe anaemia (haemoglobin <10.5 g/dL), we estimated an increased rate of mortality (hazard ratio (HR)=5.27, CI 4.37-6.35), cardiovascular hospitalizations (HR=2.18, CI 1.76-2.70) and end-stage renal disease (HR=5.46, CI 3.38-8.82) when compared with patients who were not anaemic; the HR reflect time-varying haemoglobins and eGFR.
      Conclusion: Anaemia is a predictor of excess mortality, excess cardiovascular hospitalizations and excess end-stage renal disease even when the progression of CKD is considered by controlling for time-varying eGFR values.
    • Accession Number:
      0 (Hemoglobins)
    • Publication Date:
      Date Created: 20090212 Date Completed: 20090630 Latest Revision: 20090409
    • Publication Date:
      20231215
    • Accession Number:
      10.1111/j.1440-1797.2008.01065.x
    • Accession Number:
      19207866