Long-term depression in the CNS.

Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962781 Publication Model: Print Cited Medium: Internet ISSN: 1471-0048 (Electronic) Linking ISSN: 1471003X NLM ISO Abbreviation: Nat Rev Neurosci Subsets: MEDLINE

Original Publication: London, UK : Nature Pub. Group,

Central Nervous System/*physiology ; Long-Term Potentiation/*physiology ; Long-Term Synaptic Depression/*physiology ; Neuronal Plasticity/*physiology; Animals ; Excitatory Amino Acid Agents/pharmacology ; Excitatory Amino Acid Agents/therapeutic use ; Humans ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/physiopathology ; Receptors, N-Methyl-D-Aspartate/physiology ; Signal Transduction/physiology ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/physiopathology

Long-term depression (LTD) in the CNS has been the subject of intense investigation as a process that may be involved in learning and memory and in various pathological conditions. Several mechanistically distinct forms of this type of synaptic plasticity have been identified and their molecular mechanisms are starting to be unravelled. Most studies have focused on forms of LTD that are triggered by synaptic activation of either NMDARs (N-methyl-D-aspartate receptors) or metabotropic glutamate receptors (mGluRs). Converging evidence supports a crucial role of LTD in some types of learning and memory and in situations in which cognitive demands require a flexible response. In addition, LTD may underlie the cognitive effects of acute stress, the addictive potential of some drugs of abuse and the elimination of synapses in neurodegenerative diseases.

G0601813 United Kingdom MRC_ Medical Research Council; United States HHMI Howard Hughes Medical Institute

0 (Excitatory Amino Acid Agents)
0 (Receptors, N-Methyl-D-Aspartate)

Date Created: 20100619 Date Completed: 20110421 Latest Revision: 20250529

20250530

10.1038/nrn2867

20559335