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European ancestry decreases the risk of early onset, severe lupus nephritis in a single center, multiethnic pediatric lupus inception cohort.

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  • Author(s): Frankovich JD;Frankovich JD; Hsu JJ; Sandborg CI
  • Source:
    Lupus [Lupus] 2012 Apr; Vol. 21 (4), pp. 421-9.
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE
    • Publication Information:
      Publication: London : SAGE Publications
      Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991-
    • Subject Terms:
      Lupus Erythematosus, Systemic/*ethnology ; Lupus Nephritis/*ethnology ; White People/*statistics & numerical data; Adolescent ; Age of Onset ; California/epidemiology ; Chi-Square Distribution ; Child ; Communication Barriers ; Disease Progression ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Language ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/therapy ; Lupus Nephritis/diagnosis ; Lupus Nephritis/prevention & control ; Male ; Prognosis ; Proportional Hazards Models ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Socioeconomic Factors ; Time Factors
    • Abstract:
      Purpose: To determine whether pediatric SLE patients without European ancestry are at higher risk for development of severe lupus nephritis (ISN/RPS class III, IV or V).
      Methods: Ninety-eight of 101 patients with pediatric SLE (age <18 years at diagnosis) were enrolled. Race/ethnicity of four grandparents, socioeconomic status (SES) and language proficiency were collected. The primary outcome was time to development of severe lupus nephritis.
      Results: Based on patient report of four grandparent ancestry, 29% had at least one grandparent of European ancestry (14% had all four grandparents of European ancestry). Patients without European ancestry were 46% Hispanic, 47% Asian, and 3% African American. In the entire 98 patient cohort, 12% had ≥3 different ancestries. Patients without European ancestry had significantly lower SES levels and English proficiency. There was no significant difference between patients with or without European ancestry in duration of SLE, age of onset, and lag time between symptoms and diagnosis. Patients with at least one grandparent of European ancestry had a decreased risk of developing severe lupus nephritis, which remained significant after controlling for age, gender, SES and English proficiency (hazard ratio 0.4, 95% confidence interval 0.2-0.9).
      Conclusion: This study demonstrates that presence of at least one grandparent of European ancestry decreases the risk of severe lupus nephritis, a finding that is not explained by measurable socioeconomic differences and language barriers.
    • Grant Information:
      5UL1RR025744-03 United States RR NCRR NIH HHS
    • Publication Date:
      Date Created: 20120320 Date Completed: 20120716 Latest Revision: 20221207
    • Publication Date:
      20240513
    • Accession Number:
      10.1177/0961203312437805
    • Accession Number:
      22427363