Genetic diversity and selection in three Plasmodium vivax merozoite surface protein 7 (Pvmsp-7) genes in a Colombian population.

Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Original Publication: San Francisco, CA : Public Library of Science

Gene Expression Regulation* ; Genetic Variation*; Malaria/*parasitology ; Membrane Proteins/*chemistry ; Membrane Proteins/*genetics ; Plasmodium vivax/*genetics ; Protozoan Proteins/*chemistry ; Protozoan Proteins/*genetics; Alleles ; Amino Acid Sequence ; Antimalarials/pharmacology ; Colombia ; Evolution, Molecular ; Humans ; Linkage Disequilibrium ; Models, Genetic ; Molecular Sequence Data ; Plasmodium vivax/physiology ; Polymorphism, Genetic ; Protein Structure, Tertiary ; Recombinant Proteins/metabolism ; Recombination, Genetic ; Sequence Homology, Amino Acid ; Species Specificity

A completely effective vaccine for malaria (one of the major infectious diseases worldwide) is not yet available; different membrane proteins involved in parasite-host interactions have been proposed as candidates for designing it. It has been found that proteins encoded by the merozoite surface protein (msp)-7 multigene family are antibody targets in natural infection; the nucleotide diversity of three Pvmsp-7 genes was thus analyzed in a Colombian parasite population. By contrast with P. falciparum msp-7 loci and ancestral P. vivax msp-7 genes, specie-specific duplicates of the latter specie display high genetic variability, generated by single nucleotide polymorphisms, repeat regions, and recombination. At least three major allele types are present in Pvmsp-7C, Pvmsp-7H and Pvmsp-7I and positive selection seems to be operating on the central region of these msp-7 genes. Although this region has high genetic polymorphism, the C-terminus (Pfam domain ID: PF12948) is conserved and could be an important candidate when designing a subunit-based antimalarial vaccine.

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0 (Antimalarials)
0 (Membrane Proteins)
0 (Protozoan Proteins)
0 (Recombinant Proteins)
0 (merozoite surface protein 7, Plasmodium)

Date Created: 20121011 Date Completed: 20130507 Latest Revision: 20211021

20240513

PMC3458108

10.1371/journal.pone.0045962

23049905