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Korean red ginseng extract exhibits neuroprotective effects through inhibition of apoptotic cell death.
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- Author(s): Kim S;Kim S; Lee Y; Cho J
- Source:
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2014; Vol. 37 (6), pp. 938-46.
- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
- Language:
English
- Additional Information
- Source:
Publisher: Pharmaceutical Society of Japan Country of Publication: Japan NLM ID: 9311984 Publication Model: Print Cited Medium: Internet ISSN: 1347-5215 (Electronic) Linking ISSN: 09186158 NLM ISO Abbreviation: Biol Pharm Bull Subsets: MEDLINE
- Publication Information:
Original Publication: Tokyo : Pharmaceutical Society of Japan, c1993-
- Subject Terms:
- Abstract:
Red ginseng has long been used as a traditional medicine in many East Asian countries including Korea. It is known to exhibit various pharmacological effects, including anti-oxidant, anti-cancer, anti-stress and anti-diabetes activities. To further explore its actions, the present study evaluated effects of Korean red ginseng (KRG) extract on neuronal injury induced by various types of insults using primary cultured rat cortical cells. KRG extract inhibited neuronal damage and generation of intracellular reactive oxygen species (ROS) induced by excitatory amino acids, such as glutamate and N-methyl-D-aspartate (NMDA), or by Aβ(25-35). To elucidate possible mechanism(s) by which KRG extract exerts neuroprotective action, its effects on apoptosis and apoptosis-related signaling molecules in neurons were assessed. KRG extract markedly increased phosphorylation of Bad at Ser 112 and inhibited Bax expression and caspase 3 activity. It also inhibited DNA fragmentation induced by NMDA or Aβ(25-35). These results indicate that KRG extract protects cultured neurons from excitotoxicity and Aβ(25-35)-induced toxicity through inhibition of ROS generation and apoptotic cell death. In addition, KRG extract inhibited β-secretase activity, implying that it may reduce Aβ peptide formation. Taken together, these findings suggest that KRG extract may be beneficial for the prevention and/or treatment of neurodegenerative disorders including Alzheimer's disease.
- Accession Number:
0 (Amyloid beta-Peptides)
0 (Glutamates)
0 (Neuroprotective Agents)
0 (Peptide Fragments)
0 (Plant Extracts)
0 (Reactive Oxygen Species)
0 (amyloid beta-protein (25-35))
- Publication Date:
Date Created: 20140603 Date Completed: 20150120 Latest Revision: 20220409
- Publication Date:
20250114
- Accession Number:
10.1248/bpb.b13-00880
- Accession Number:
24882407
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