Selenium-enriched foods are more effective at increasing glutathione peroxidase (GPx) activity compared with selenomethionine: a meta-analysis.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Dietary Supplements* ; Food, Fortified*; Glutathione Peroxidase/*metabolism ; Selenium/*pharmacology ; Selenomethionine/*pharmacology; Animal Feed ; Animals ; Dose-Response Relationship, Drug ; Erythrocytes/drug effects ; Erythrocytes/metabolism ; Kidney/drug effects ; Kidney/metabolism ; Muscles/drug effects ; Muscles/metabolism ; Selenium/administration & dosage ; Selenomethionine/administration & dosage ; Species Specificity

Selenium may play a beneficial role in multi-factorial illnesses with genetic and environmental linkages via epigenetic regulation in part via glutathione peroxidase (GPx) activity. A meta-analysis was undertaken to quantify the effects of dietary selenium supplementation on the activity of overall GPx activity in different tissues and animal species and to compare the effectiveness of different forms of dietary selenium. GPx activity response was affected by both the dose and form of selenium (p < 0.001). There were differences between tissues on the effects of selenium supplementation on GPx activity (p < 0.001); however, there was no evidence in the data of differences between animal species (p = 0.95). The interactions between dose and tissue, animal species and form were significant (p < 0.001). Tissues particularly sensitive to changes in selenium supply include red blood cells, kidney and muscle. The meta-analysis identified that for animal species selenium-enriched foods were more effective than selenomethionine at increasing GPx activity.

J Nutr. 1997 Nov;127(11):2165-72. (PMID: 9349843)
Comp Biochem Physiol B Biochem Mol Biol. 1997 May;117(1):109-14. (PMID: 9180019)
J Neurosci Res. 1995 Dec;42(5):684-91. (PMID: 8600301)
Mol Nutr Food Res. 2012 Dec;56(12):1812-24. (PMID: 23097236)
Am J Clin Nutr. 2012 Oct;96(4):923-31. (PMID: 22952184)
Prostate. 2009 Nov 1;69(15):1635-42. (PMID: 19623542)
Biochem Biophys Res Commun. 1997 May 19;234(2):293-5. (PMID: 9177261)
Annu Rev Nutr. 2008;28:157-77. (PMID: 18494599)
Am J Clin Nutr. 2010 Sep;92(3):525-31. (PMID: 20573787)
Cancer Chemother Pharmacol. 2011 Sep;68(3):815-21. (PMID: 21519842)
Biochim Biophys Acta. 1989 Nov 6;1006(1):140-3. (PMID: 2804065)
Carcinogenesis. 2009 Aug;30(8):1416-23. (PMID: 19528666)
Nutrients. 2014 Mar 24;6(3):1251-61. (PMID: 24667132)
Am J Clin Nutr. 2010 Apr;91(4):923-31. (PMID: 20181815)
Br J Nutr. 2008 Jun;99(6):1190-8. (PMID: 18062829)
J Nutr. 1985 Jun;115(6):733-42. (PMID: 3998867)
BMJ. 2009 Jul 21;339:b2700. (PMID: 19622552)
PLoS Med. 2009 Jul 21;6(7):e1000097. (PMID: 19621072)
J Agric Food Chem. 2011 Nov 9;59(21):11424-31. (PMID: 21942342)
Exp Biol Med (Maywood). 2010 Sep;235(9):1046-52. (PMID: 20724535)
Br J Nutr. 2010 Jul;104(1):17-23. (PMID: 20346189)
Front Mol Neurosci. 2011 Jul 28;4:12. (PMID: 21847368)
J Mol Endocrinol. 1998 Apr;20(2):203-10. (PMID: 9584835)
Biol Trace Elem Res. 2014 Jun;159(1-3):69-80. (PMID: 24811888)
Biol Trace Elem Res. 2011 Aug;142(2):223-31. (PMID: 20632125)
J Nutr. 2001 Sep;131(9):2343-50. (PMID: 11533277)
J Nutr. 2011 Aug;141(8):1464-8. (PMID: 21653573)
PLoS One. 2013 May 23;8(5):e64362. (PMID: 23717604)
Adv Nutr. 2011 Nov;2(6):497-510. (PMID: 22332092)
Biochem Pharmacol. 1999 Jan 15;57(2):187-93. (PMID: 9890567)
Biol Trace Elem Res. 1996 Mar;51(3):211-23. (PMID: 8727669)
J Nutr Biochem. 2001 Feb;12(2):88-94. (PMID: 11182551)
J Nutr. 1986 Jun;116(6):1068-79. (PMID: 3723202)
Antioxid Redox Signal. 2008 Sep;10(9):1501-14. (PMID: 18498225)
J Anim Sci. 1996 Dec;74(12):2967-74. (PMID: 8994911)
Biol Trace Elem Res. 2003 May;92(2):161-72. (PMID: 12746575)
Nutr J. 2011 Jul 18;10:75. (PMID: 21767397)
Eur J Nutr. 2013 Jun;52(4):1327-41. (PMID: 22923034)
Cancer Res. 2008 Jun 15;68(12):4936-44. (PMID: 18559541)
Endocrinology. 1992 Jul;131(1):479-84. (PMID: 1612029)
Carcinogenesis. 2008 Nov;29(11):2175-81. (PMID: 18676679)
Biochem J. 1990 Mar 15;266(3):743-7. (PMID: 2327962)
J Biol Chem. 2009 Feb 27;284(9):5731-41. (PMID: 19073608)
J Nutr. 2007 May;137(5):1132-6. (PMID: 17449570)
Am J Clin Nutr. 2008 Apr;87(4):1019-27. (PMID: 18400727)
J Agric Food Chem. 2014 May 21;62(20):4502-8. (PMID: 24814575)
Am J Clin Nutr. 2009 Jun;89(6):2025S-2039S. (PMID: 19420095)
Biochem J. 2009 Jul 29;422(1):11-22. (PMID: 19627257)
J Anim Sci. 2008 Nov;86(11):3100-9. (PMID: 18567732)
Annu Rev Nutr. 1999;19:1-16. (PMID: 10448514)
Br J Nutr. 2008 Apr;99(4):883-92. (PMID: 17888202)
Br J Nutr. 2008 Jun;99 Suppl 3:S37-47. (PMID: 18598587)
Biochem Pharmacol. 1984 Aug 15;33(16):2635-9. (PMID: 6466377)
Biochim Biophys Acta. 2013 May;1830(5):3289-303. (PMID: 23201771)
J Nutr. 1974 Aug;104(8):1069-78. (PMID: 4851627)
J Biol Chem. 2009 Jan 9;284(2):723-7. (PMID: 18757362)
Oncogene. 2013 Aug 22;32(34):4043-51. (PMID: 22964634)
Food Chem Toxicol. 2008 Nov;46(11):3501-5. (PMID: 18809457)
Antioxid Redox Signal. 2011 Apr 1;14(7):1337-83. (PMID: 20812787)
J Anim Sci. 2006 Jul;84(7):1742-8. (PMID: 16775058)
Cancer Res. 2007 Sep 1;67(17):8043-50. (PMID: 17804715)
PLoS One. 2011 Mar 21;6(3):e14771. (PMID: 21445287)
J Biol Chem. 2014 May 30;289(22):15350-62. (PMID: 24719327)
J Nutr. 2009 Feb;139(2):199-206. (PMID: 19106321)
Mol Nutr Food Res. 2013 Dec;57(12):2195-205. (PMID: 23934683)
Biochem J. 1995 Oct 15;311 ( Pt 2):425-30. (PMID: 7487877)
Biol Trace Elem Res. 2000 Feb;73(2):113-25. (PMID: 11049204)
Biol Trace Elem Res. 1993 Jan;36(1):15-23. (PMID: 7681678)
J Nutr. 1987 Apr;117(4):725-31. (PMID: 3585522)
Int J Cancer. 2007 Dec 1;121(11):2381-6. (PMID: 17893868)
Mol Carcinog. 2015 Oct;54(10):1051-9. (PMID: 24789055)
Anticancer Res. 2007 Mar-Apr;27(2):921-5. (PMID: 17465221)
Exp Biol Med (Maywood). 2009 Nov;234(11):1271-9. (PMID: 19855070)
Clin Chem Lab Med. 2007;45(3):321-7. (PMID: 17378726)
Wei Sheng Yan Jiu. 2012 Jan;41(1):120-3. (PMID: 22443071)
Nutr Res. 2011 Feb;31(2):165-8. (PMID: 21419321)
FASEB J. 2007 Oct;21(12):3063-74. (PMID: 17536041)
J Anim Sci. 1999 Aug;77(8):2172-9. (PMID: 10461996)
Br J Nutr. 2011 Aug;106(4):572-82. (PMID: 21450115)
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12796-800. (PMID: 17646663)
Gut. 2009 Jan;58(1):5-15. (PMID: 18664505)
FASEB J. 1998 Aug;12(11):949-57. (PMID: 9707167)
Br J Nutr. 2012 May;107(10):1514-25. (PMID: 21936966)
Biochim Biophys Acta. 1997 Oct 30;1359(1):25-34. (PMID: 9398082)
J Nutr. 2006 Aug;136(8):2232-5. (PMID: 16857846)
Comp Biochem Physiol B Biochem Mol Biol. 2003 Dec;136(4):921-34. (PMID: 14662314)
Br J Nutr. 1993 Mar;69(2):577-88. (PMID: 8490010)
Free Radic Biol Med. 2012 Aug 1;53(3):488-97. (PMID: 22634395)
Biol Trace Elem Res. 2011 Nov;143(2):1209-18. (PMID: 21181292)
Genes Nutr. 2012 Apr;7(2):155-65. (PMID: 21847681)
Biochem J. 1992 Mar 1;282 ( Pt 2):483-6. (PMID: 1546962)
Biochem J. 1987 Dec 1;248(2):443-7. (PMID: 3435458)
Free Radic Res. 2007 Feb;41(2):162-71. (PMID: 17364942)
Cancer Prev Res (Phila). 2009 Jul;2(7):683-93. (PMID: 19584079)
J Trace Elem Electrolytes Health Dis. 1993 Dec;7(4):242-4. (PMID: 8019157)
J Trace Elem Med Biol. 2009;23(1):29-35. (PMID: 19203714)
J Agric Food Chem. 2013 Mar 13;61(10):2385-91. (PMID: 23360166)
J Neurochem. 2009 Jul;110(1):133-42. (PMID: 19453374)
J Nutr. 2002 Aug;132(8 Suppl):2393S-2400S. (PMID: 12163699)
Free Radic Biol Med. 1998 Sep;25(4-5):504-11. (PMID: 9741586)
Biochem J. 1987 Dec 1;248(2):539-44. (PMID: 3435464)
J Anim Physiol Anim Nutr (Berl). 2009 Jun;93(3):313-24. (PMID: 19646106)
Nutr Cancer. 2013;65(3):355-66. (PMID: 23530634)
J Trace Elem Med Biol. 1995 Jul;9(2):65-73. (PMID: 8825978)
J Nutr. 2008 Dec;138(12):2328-36. (PMID: 19022953)
Am J Clin Nutr. 1991 Jan;53(1):120-5. (PMID: 1984336)
J Nutr. 2000 Dec;130(12):2903-9. (PMID: 11110844)
J Trace Elem Med Biol. 1998 Mar;12(1):8-15. (PMID: 9638607)
Funct Integr Genomics. 2005 Jul;5(3):129-35. (PMID: 15875226)
Genes Nutr. 2007 Nov;2(2):225-32. (PMID: 18850177)
Nutrients. 2013 Jan 31;5(2):340-58. (PMID: 23434902)
Am J Clin Nutr. 2005 Apr;81(4):829-34. (PMID: 15817859)
Biol Trace Elem Res. 2006 Feb;109(2):145-54. (PMID: 16444004)
Annu Rev Nutr. 2014;34:337-55. (PMID: 24850387)
Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):804-10. (PMID: 16614127)

964MRK2PEL (Selenomethionine)
EC 1.11.1.9 (Glutathione Peroxidase)
H6241UJ22B (Selenium)

Date Created: 20141001 Date Completed: 20151022 Latest Revision: 20211021

20250114

PMC4210904

10.3390/nu6104002

25268836