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Mediation analysis of gestational age, congenital heart defects, and infant birth-weight.

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  • Author(s): Wogu AF; Loffredo CA; Loffredo CA; Bebu I; Luta G
  • Source:
    BMC research notes [BMC Res Notes] 2014 Dec 17; Vol. 7, pp. 926. Date of Electronic Publication: 2014 Dec 17.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Biomed Central, 2008.
    • Subject Terms:
      Birth Weight* ; Gestational Age*; Heart Defects, Congenital/*epidemiology ; Risk Assessment/*statistics & numerical data; Adult ; Case-Control Studies ; District of Columbia/epidemiology ; Educational Status ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Maryland/epidemiology ; Maternal Age ; Mothers ; Risk Assessment/methods ; Risk Factors ; Smoking ; Virginia/epidemiology
    • Abstract:
      Background: In this study we assessed the mediation role of the gestational age on the effect of the infant's congenital heart defects (CHD) on birth-weight.
      Methods: We used secondary data from the Baltimore-Washington Infant Study (1981-1989). Mediation analysis was employed to investigate whether gestational age acted as a mediator of the association between CHD and reduced birth-weight. We estimated the mediated effect, the mediation proportion, and their corresponding 95% confidence intervals (CI) using several methods.
      Results: There were 3362 CHD cases and 3564 controls in the dataset with mean birth-weight of 3071 (SD = 729) and 3353 (SD = 603) grams, respectively; the mean gestational age was 38.9 (SD = 2.7) and 39.6 (SD = 2.2) weeks, respectively. After adjusting for covariates, the estimated mediated effect by gestational age was 113.5 grams (95% CI, 92.4-134.2) and the mediation proportion was 40.7% (95% CI, 34.7%-46.6%), using the bootstrap approach.
      Conclusions: Gestational age may account for about 41% of the overall effect of heart defects on reduced infant birth-weight. Improved prenatal care and other public health efforts that promote full term delivery, particularly targeting high-risk families and mothers known to be carrying a fetus with CHD, may therefore be expected to improve the birth-weight of these infants and their long term health.
    • References:
      J Perinatol. 2004 Apr;24(4):236-40. (PMID: 15014534)
      Soc Biol. 2000 Spring-Summer;47(1-2):77-93. (PMID: 11521458)
      Am J Med Genet. 2000 Winter;97(4):319-25. (PMID: 11376444)
      Eur J Pediatr. 2012 Feb;171(2):281-7. (PMID: 21748291)
      Psychol Methods. 2002 Dec;7(4):422-45. (PMID: 12530702)
      Am J Epidemiol. 1998 Sep 1;148(5):414-23. (PMID: 9737553)
      Annu Rev Psychol. 2007;58:593-614. (PMID: 16968208)
      J Epidemiol Community Health. 2012 Feb;66(2):136-42. (PMID: 21081308)
      Pediatrics. 2012 Oct;130(4):e829-37. (PMID: 22945415)
      Matern Child Health J. 2009 Mar;13(2):164-75. (PMID: 18484173)
      ISRN Obstet Gynecol. 2012;2012:540495. (PMID: 22991672)
      Pediatrics. 2011 Jan;127(1):146-57. (PMID: 21173001)
      Psychol Methods. 2010 Dec;15(4):309-34. (PMID: 20954780)
      Am J Epidemiol. 1991 Jun 15;133(12):1273-81. (PMID: 2063835)
      Paediatr Perinat Epidemiol. 1990 Oct;4(4):381-90. (PMID: 2267179)
      Pediatrics. 2008 Apr;121(4):e810-6. (PMID: 18381510)
      Circulation. 2011 Jun 21;123(24):2792-8. (PMID: 21632494)
      Am J Epidemiol. 2009 Dec 1;170(11):1443-8. (PMID: 19850625)
      J Am Coll Cardiol. 2007 Sep 25;50(13):1263-71. (PMID: 17888844)
      Circulation. 1975 Sep;52(3):500-3. (PMID: 1157251)
      Acta Obstet Gynecol Scand. 2010 Jul;89(7):862-75. (PMID: 20583931)
      Acad Emerg Med. 2005 Apr;12(4):360-5. (PMID: 15805329)
      Psychol Methods. 2011 Jun;16(2):93-115. (PMID: 21500915)
      Pediatrics. 2011 Feb;127(2):293-9. (PMID: 21220403)
      Indian Pediatr. 1994 May;31(5):519-27. (PMID: 7875882)
      Arch Dis Child. 1986 Jun;61(6):559-64. (PMID: 2425752)
      Eur J Obstet Gynecol Reprod Biol. 2006 Apr 1;125(2):211-6. (PMID: 16137818)
      Arch Dis Child Fetal Neonatal Ed. 2000 Nov;83(3):F182-5. (PMID: 11040165)
      Pediatrics. 2007 Apr;119(4):e976-82. (PMID: 17387169)
      Pediatrics. 2011 Mar;127(3):e647-53. (PMID: 21357347)
      Diabetes Care. 2002 Oct;25(10):1761-5. (PMID: 12351474)
      BMC Med Res Methodol. 2005;5:32. (PMID: 16221306)
      J Pediatr. 2009 Apr;154(4):498-503.e2. (PMID: 19111322)
      Eur J Epidemiol. 1999 Sep;15(8):731-7. (PMID: 10555617)
      BMC Public Health. 2007;7:192. (PMID: 17683559)
      Stat Med. 1992 Jan 30;11(2):167-78. (PMID: 1579756)
      Pediatrics. 2005 Dec;116(6):e833-8. (PMID: 16322141)
      Behav Res Methods Instrum Comput. 2004 Nov;36(4):717-31. (PMID: 15641418)
      Eur J Epidemiol. 2003;18(3):235-43. (PMID: 12800948)
      Biometrics. 1998 Sep;54(3):1014-29. (PMID: 9840970)
      Stat Med. 2000 May 15;19(9):1141-64. (PMID: 10797513)
      J Pers Soc Psychol. 1986 Dec;51(6):1173-82. (PMID: 3806354)
      Isr Med Assoc J. 2010 Jan;12(1):36-8. (PMID: 20450127)
      Pediatrics. 2012 Feb;129(2):338-48. (PMID: 22291121)
      Pediatrics. 2011 Feb;127(2):385-6. (PMID: 21220400)
    • Publication Date:
      Date Created: 20141218 Date Completed: 20150910 Latest Revision: 20181113
    • Publication Date:
      20240513
    • Accession Number:
      PMC4320577
    • Accession Number:
      10.1186/1756-0500-7-926
    • Accession Number:
      25515761