[Intensity of functional connection between bilateral hemispheres of children with attention-deficit hyperactivity disorder by functional magnetic resonance imaging].

Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 7511141 Publication Model: Print Cited Medium: Print ISSN: 0376-2491 (Print) Linking ISSN: 03762491 NLM ISO Abbreviation: Zhonghua Yi Xue Za Zhi Subsets: MEDLINE

Publication: Beijing : Zhonghua yi xue hui
Original Publication: Beijing : Zhonghua yi xue hui.

Attention Deficit Disorder with Hyperactivity* ; Magnetic Resonance Imaging*; Brain ; Brain Mapping ; Child ; Humans ; Memory, Short-Term

Objective: To explore the neural mechanisms of attention-deficit hyperactivity disorder (ADHD) through analyzing the intensity of functional connection between bilateral hemispheres of children with ADHD by resting-state functional magnetic resonance imaging (rs-fMRI).
Methods: The approach of voxel-mirrored homotopic connectivity (VMHC) was employed to analyze 31 school-age and 31 ADHD children by rs-fMRI scans.
Results: Positively activated brain regions were visualized when comparing ADHD and normal children, suggesting that ADHD children's VMHC scores were higher in bilateral frontal lobe (t = 5.81), bilateral occipital lobe (t = 5.82) and bilateral cerebellar posterior lobe (t = 6.17). Statistically significant differences existed between two groups (FDR correction, Q<0.01).
Conclusions: The increased intensity of functional connection between bilateral prefrontal lobes in children with ADHD reflects attention disorder and leads to a decline of working memory . The strengthening of bilateral occipital lobes slows down memory process. And the increased intensity of cerebellar connections may damage neural circuits and aggravate ADHD symptoms.

Date Created: 20150128 Date Completed: 20150913 Latest Revision: 20181202

20231215

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