Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

EXPRESS: Oligodendrocytes in HIV-associated pain pathogenesis.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Author(s): Shi Y;Shi Y; Shu J; Shu J; Liang Z; Liang Z; Yuan S; Yuan S; Tang SJ; Tang SJ
  • Source:
    Molecular pain [Mol Pain] 2016 Jun 15; Vol. 12. Date of Electronic Publication: 2016 Jun 15 (Print Publication: 2016).
  • Publication Type:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Sage Publications Inc Country of Publication: United States NLM ID: 101242662 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1744-8069 (Electronic) Linking ISSN: 17448069 NLM ISO Abbreviation: Mol Pain Subsets: MEDLINE
    • Publication Information:
      Publication: 2016- : Thousand Oaks, CA : Sage Publications Inc.
      Original Publication: [London] : BioMed Central, 2005-
    • Subject Terms:
      HIV Infections/*complications ; HIV Infections/*pathology ; Oligodendroglia/*pathology ; Pain/*etiology ; Pain/*pathology; Animals ; Biomarkers/metabolism ; Gene Knockdown Techniques ; HIV Envelope Protein gp120/metabolism ; HIV Infections/metabolism ; Humans ; Hyperalgesia/metabolism ; Hyperalgesia/pathology ; Mice, Inbred C57BL ; Mice, Knockout ; Myelin Basic Protein/metabolism ; Myelin Sheath/metabolism ; Oligodendroglia/metabolism ; Pain/metabolism ; Spinal Cord Dorsal Horn/metabolism ; Spinal Cord Dorsal Horn/pathology ; Up-Regulation
    • Abstract:
      Background: Although the contributions of microglia and astrocytes to chronic pain pathogenesis have been a focal point of investigation in recent years, the potential role of oligodendrocytes, another major type of glial cells in the CNS that generates myelin, remains largely unknown.
      Results: We report here that cell markers of the oligodendrocyte lineage, including NG2, PDGFRa, and Olig2, are significantly increased in the spinal dorsal horn of HIV patients who developed chronic pain. The levels of myelin proteins myelin basic protein and proteolipid protein are also aberrant in the spinal dorsal horn of "pain-positive" HIV patients. Similarly, the oligodendrocyte and myelin markers are up-regulated in the spinal dorsal horn of a mouse model of HIV-1 gp120-induced pain. Surprisingly, the expression of gp120-induced mechanical allodynia appears intact up to 4 h after myelin basic protein is knocked down or knocked out.
      Conclusion: These findings suggest that oligodendrocytes are reactive during the pathogenesis of HIV-associated pain. However, interfering with myelination does not alter the induction of gp120-induced pain.
    • References:
      AIDS. 2011 Apr 24;25(7):919-28. (PMID: 21330902)
      Cell Mol Neurobiol. 2011 Nov;31(8):1129-39. (PMID: 21630006)
      Ann Neurol. 2014 Jun;75(6):837-50. (PMID: 24633867)
      Nat Rev Neurosci. 2010 Apr;11(4):275-83. (PMID: 20216548)
      Pain. 2008 Mar;135(1-2):37-47. (PMID: 17560721)
      Pain. 2015 Jul;156(7):1311-9. (PMID: 25840108)
      Mol Pain. 2005 Sep 28;1:29. (PMID: 16191203)
      Pain. 1997 Apr;70(2-3):117-23. (PMID: 9150284)
      CNS Drugs. 2005;19(4):325-34. (PMID: 15813646)
      J Neurosci. 2001 Apr 15;21(8):2808-19. (PMID: 11306633)
      Mol Pain. 2012 Jun 19;8:47. (PMID: 22713358)
      Lancet. 2008 Oct 25;372(9648):1502-17. (PMID: 18970977)
      Brain Behav Immun. 2007 Jul;21(5):660-7. (PMID: 17204394)
      Pain. 2005 May;115(1-2):71-83. (PMID: 15836971)
      J Neurosci Methods. 1994 Jul;53(1):55-63. (PMID: 7990513)
      Pain. 1997 Jul;71(3):225-35. (PMID: 9231865)
      Mol Pain. 2011 May 20;7:40. (PMID: 21599974)
      J Peripher Nerv Syst. 2001 Mar;6(1):14-20. (PMID: 11293802)
      Ann Neurol. 2004 Apr;55(4):458-68. (PMID: 15048884)
      Brain Res. 1980 Jun 2;191(1):278-83. (PMID: 6155168)
      J Neurotrauma. 2006 Mar-Apr;23(3-4):345-59. (PMID: 16629621)
      Nature. 2012 Apr 29;485(7399):517-21. (PMID: 22622581)
      J Assoc Nurses AIDS Care. 2010 Mar-Apr;21(2):125-33. (PMID: 20116299)
      Physiol Rev. 2001 Apr;81(2):871-927. (PMID: 11274346)
      J Hered. 1981 Mar-Apr;72(2):128. (PMID: 6168677)
      Arch Virol. 1994;137(1-2):81-99. (PMID: 7526826)
      J Pain. 2008 Feb;9(2):174-84. (PMID: 18088557)
      Brain Pathol. 1991 Apr;1(3):143-52. (PMID: 1669703)
      J Biol Chem. 2013 May 10;288(19):13610-9. (PMID: 23539626)
      J Neuroimmune Pharmacol. 2013 Sep;8(4):956-64. (PMID: 23737037)
      J Neuroimmune Pharmacol. 2011 Dec;6(4):650-7. (PMID: 21286834)
      Headache. 1999 Jan;39(1):3-10. (PMID: 15613188)
      Cell. 1985 Aug;42(1):149-55. (PMID: 2410137)
      J Neuroimmune Pharmacol. 2010 Sep;5(3):294-309. (PMID: 20396973)
      AIDS. 2002 May 3;16(7):1019-29. (PMID: 11953468)
      J Immunol. 2012 Oct 1;189(7):3724-33. (PMID: 22956581)
      Nature. 2012 Jul 26;487(7408):443-8. (PMID: 22801498)
      Neuropathol Appl Neurobiol. 2001 Aug;27(4):326-35. (PMID: 11532163)
      Eur Neurol. 2004;52(1):36-41. (PMID: 15237251)
      J Neurosci. 2012 Aug 8;32(32):10833-40. (PMID: 22875918)
      Pain. 2007 Dec 15;133(1-3):47-63. (PMID: 17433546)
      J Neurotrauma. 1992 Mar;9 Suppl 1:S105-17. (PMID: 1588601)
      Neuron Glia Biol. 2006 Nov;2(4):259-69. (PMID: 17710215)
      Pain. 2000 Mar;85(1-2):191-200. (PMID: 10692618)
      FASEB J. 2016 Jan;30(1):54-65. (PMID: 26310268)
      Clin Biochem. 1991 Apr;24(2):113-34. (PMID: 1710177)
      Nat Rev Neurol. 2014 Jun;10(6):326-36. (PMID: 24840972)
      Nat Commun. 2014 Dec 01;5:5472. (PMID: 25434649)
      Pain. 2005 Mar;114(1-2):149-59. (PMID: 15733640)
    • Grant Information:
      R01 DA036165 United States DA NIDA NIH HHS; R01 NS079166 United States NS NINDS NIH HHS; R01-DA036165 United States DA NIDA NIH HHS; R01-NS079166 United States NS NINDS NIH HHS
    • Accession Number:
      0 (Biomarkers)
      0 (HIV Envelope Protein gp120)
      0 (Myelin Basic Protein)
    • Publication Date:
      Date Created: 20160617 Date Completed: 20161226 Latest Revision: 20190814
    • Publication Date:
      20250114
    • Accession Number:
      PMC4956145
    • Accession Number:
      10.1177/1744806916656845
    • Accession Number:
      27306410