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The antiSMASH database, a comprehensive database of microbial secondary metabolite biosynthetic gene clusters.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
    • Publication Information:
      Publication: 1992- : Oxford : Oxford University Press
      Original Publication: London, Information Retrieval ltd.
    • Subject Terms:
      Biosynthetic Pathways*/genetics ; Databases, Factual* ; Microbiology* ; Secondary Metabolism*/genetics; Computational Biology/methods ; Gene Expression Regulation ; Protein Processing, Post-Translational ; Web Browser
    • Abstract:
      Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms. Therefore, we developed the antiSMASH database, a simple but highly useful new resource to browse antiSMASH-annotated BGCs in the currently 3907 bacterial genomes in the database and perform advanced search queries combining multiple search criteria. antiSMASH-DB is available at http://antismash-db.secondarymetabolites.org/.
      (© The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.)
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    • Publication Date:
      Date Created: 20161208 Date Completed: 20170615 Latest Revision: 20181113
    • Publication Date:
      20250114
    • Accession Number:
      PMC5210647
    • Accession Number:
      10.1093/nar/gkw960
    • Accession Number:
      27924032