Relationship between pre-transplant physical function and outcomes after kidney transplant.

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Author(s): Lorenz EC;Lorenz EC;Lorenz EC; Cheville AL; Cheville AL; Amer H; Amer H; Amer H; Kotajarvi BR; Kotajarvi BR; Stegall MD; Stegall MD; Stegall MD; Petterson TM; Petterson TM; Kremers WK; Kremers WK; Kremers WK; Cosio FG; Cosio FG; Cosio FG; LeBrasseur NK; LeBrasseur NK
Source:
Clinical transplantation [Clin Transplant] 2017 May; Vol. 31 (5). Date of Electronic Publication: 2017 Apr 17.
Publication Type:
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Language:
English

Additional Information
- Source:
  Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8710240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-0012 (Electronic) Linking ISSN: 09020063 NLM ISO Abbreviation: Clin Transplant Subsets: MEDLINE
- Publication Information:
  Original Publication: Copenhagen : Munksgaard,
- Subject Terms:
  Health Status* ; Kidney Transplantation* ; Quality of Life*; Kidney Failure, Chronic/*surgery; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Kidney Function Tests ; Male ; Middle Aged ; Physical Fitness ; Preoperative Period ; Prognosis ; Prospective Studies ; Risk Factors
- Abstract:
  Background: Performance-based measures of physical function predict morbidity following non-transplant surgery. Study objectives were to determine whether physical function predicts outcomes after kidney transplant and assess how physical function changes post-transplant.
  Methods: We conducted a prospective study involving living donor kidney transplants recipients at our center from May 2012 to February 2014. Physical function was measured using the Short Physical Performance Battery (SPPB [balance, chair stands, gait speed]) and grip strength testing. Initial length of stay (LOS), 30- day rehospitalizations, allograft function, and quality of life (QOL) were assessed.
  Results: The majority of the 140 patients in our cohort had excellent pre-transplant physical function. In general, balance scores were more predictive of post-transplant outcomes than the SPPB. Decreased pre-transplant balance was independently associated with longer LOS and increased rehospitalizations but not with post-transplant QOL; 35% of patients experienced a clinically meaningful (≥ 1.0 m/s) improvement in gait speed 4 months post-transplant.
  Conclusions: Decreased physical function may be associated with longer LOS and rehospitalizations following kidney transplant. Further studies are needed to confirm this association. The lack of relationship between pre-transplant gait speed and outcomes in our cohort may represent a ceiling effect. More comprehensive measures, including balance testing, may be required for risk stratification.
  (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Comments:
  Erratum in: Clin Transplant. 2017 Aug;31(8):. (PMID: 28779514)
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- Grant Information:
  UL1 TR000135 United States TR NCATS NIH HHS
- Contributed Indexing:
  Keywords: glomerular filtration rate (GFR); hospital readmission; kidney transplantation: living donor; quality of life (QOL)
- Publication Date:
  Date Created: 20170316 Date Completed: 20180326 Latest Revision: 20181113
- Publication Date:
  20231215
- Accession Number:
  PMC5416778
- Accession Number:
  10.1111/ctr.12952
- Accession Number:
  28295612

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