Physiological activities of the combination of fish oil and α-lipoic acid affecting hepatic lipogenesis and parameters related to oxidative stress in rats.

Publisher: Steinkopff Country of Publication: Germany NLM ID: 100888704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-6215 (Electronic) Linking ISSN: 14366207 NLM ISO Abbreviation: Eur J Nutr Subsets: MEDLINE

Original Publication: Darmstadt, Germany : Steinkopff, 1999-

Oxidative Stress*; Fish Oils/*pharmacology ; Lipogenesis/*drug effects ; Thioctic Acid/*pharmacology; Animals ; Fatty Acids ; Liver ; Male ; Plant Oils ; Rats ; Rats, Sprague-Dawley

Purpose: We studied the combined effect of fish oil and α-lipoic acid on hepatic lipogenesis and fatty acid oxidation and parameters of oxidative stress in rats fed lipogenic diets high in sucrose. A control diet contained a saturated fat (palm oil) that gives high rate of hepatic lipogenesis.
Methods: Male Sprague-Dawley rats were fed diets supplemented with 0 or 2.5 g/kg α-lipoic acid and containing 0, 20, or 100 g/kg fish oil, for 21 days.
Results: α-Lipoic acid significantly reduced food intake during 0-8 days but not the later period of the experiment. Fish oil and α-lipoic acid decreased serum lipid concentrations and their combination further decreased the parameters in an additive fashion. The combination of fish oil and α-lipoic acid decreased the activity and mRNA levels of hepatic lipogenic enzymes in an additive fashion. Fish oil increased the parameters of hepatic fatty acid oxidation enzymes. α-Lipoic acid appeared to antagonize the stimulating effects of fish oil of fatty acid oxidation through reductions in the activity of some fatty acid oxidation enzymes. α-Lipoic acid attenuated fish oil-dependent increases in serum and liver malondialdehyde levels, and this compound also reduced the serum 8-hydroxy-2'-deoxyguanosine level. α-Lipoic acid affected various parameters related to the antioxidant system; fish oil also affected some of the parameters.
Conclusions: The combination of fish oil and α-lipoic acid effectively reduced serum lipid levels through the additive down-regulation of hepatic lipogenesis. α-Lipoic acid was effective in attenuating fish oil-mediated oxidative stress.

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Scientific Research C, no. 22580143 Japan Society for the Promotion of Science

Keywords: Antioxidant system; Fish oil; Hepatic lipogenesis; α-Lipoic acid

0 (Fatty Acids)
0 (Fish Oils)
0 (Plant Oils)
73Y7P0K73Y (Thioctic Acid)

Date Created: 20170322 Date Completed: 20181213 Latest Revision: 20181213

20250114

10.1007/s00394-017-1440-0

28321544