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Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer's disease.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BioMed Central Ltd.
    • Subject Terms:
      Alzheimer Disease/*blood ; Amyloid beta-Peptides/*blood ; Peptide Fragments/*blood; Aged ; Aged, 80 and over ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnostic imaging ; Amyloid beta-Peptides/cerebrospinal fluid ; Aniline Compounds ; Benzothiazoles/pharmacokinetics ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Peptide Fragments/cerebrospinal fluid ; Positron-Emission Tomography ; Psychiatric Status Rating Scales ; Republic of Korea ; Retrospective Studies ; Thiazoles ; tau Proteins/blood ; tau Proteins/cerebrospinal fluid
    • Abstract:
      Background: Soluble amyloid-β (Aβ) oligomers are the major toxic substances associated with the pathology of Alzheimer's disease (AD). The ability to measure Aβ oligomer levels in the blood would provide simple and minimally invasive tools for AD diagnostics. In the present study, the recently developed Multimer Detection System (MDS) for AD, a new enzyme-linked immunosorbent assay for measuring Aβ oligomers selectively, was used to detect Aβ oligomers in the plasma of patients with AD and healthy control individuals.
      Methods: Twenty-four patients with AD and 37 cognitively normal control individuals underwent extensive clinical evaluations as follows: blood sampling; detailed neuropsychological tests; brain magnetic resonance imaging; cerebrospinal fluid (CSF) measurement of Aβ42, phosphorylated tau protein (pTau), and total tau protein (tTau); and 11 C-Pittsburgh compound B (PIB) positron emission tomography. Pearson's correlation analyses between the estimations of Aβ oligomer levels by MDS and other conventional AD biomarkers (CSF Aβ 42 , pTau, and tTau, as well as PIB standardized uptake value ratio [PIB SUVR]) were conducted. ROC analyses were used to compare the diagnostic performance of each biomarker.
      Results: The plasma levels of Aβ oligomers by MDS were higher in patients with AD than in normal control individuals, and they correlated well with conventional AD biomarkers (levels of Aβ oligomers by MDS vs. CSF Aβ 42 , r = -0.443; PIB SUVR, r = 0.430; CSF pTau, r = 0.530; CSF tTau, r = 0.604). The sensitivity and specificity of detecting plasma Aβ oligomers by MDS for differentiating AD from the normal controls were 78.3% and 86.5%, respectively. The AUC for plasma Aβ oligomers by MDS was 0.844, which was not significantly different from the AUC of other biomarkers (p = 0.250).
      Conclusions: Plasma levels of Aβ oligomers could be assessed using MDS, which might be a simple, noninvasive, and accessible assay for evaluating brain amyloid deposition related to AD pathology.
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    • Contributed Indexing:
      Keywords: Alzheimer’s disease; Amyloid-β protein; Biomarker; Oligomer
    • Accession Number:
      0 (2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole)
      0 (Amyloid beta-Peptides)
      0 (Aniline Compounds)
      0 (Benzothiazoles)
      0 (Peptide Fragments)
      0 (Thiazoles)
      0 (amyloid beta-protein (1-42))
      0 (tau Proteins)
    • Publication Date:
      Date Created: 20171217 Date Completed: 20180723 Latest Revision: 20220409
    • Publication Date:
      20250114
    • Accession Number:
      PMC5732503
    • Accession Number:
      10.1186/s13195-017-0324-0
    • Accession Number:
      29246249